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Quinazolinones

Known as: Quinazolinones [Chemical/Ingredient] 
Chemicals with two conjoined aromatic rings incorporating two nitrogen atoms and one of the carbons oxidized with a keto oxygen.
National Institutes of Health

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2-hydroxytryptanthrin2-mercapto-4(3H)-quinazolinone2-methyl-4(3H)-quinazolinone3-benzyl-4(3H)quinazolinone
In Bloodagonistsantagonists & inhibitorschemical synthesis

Papers overview

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2019
2019
Efficient Synthesis of Quinazolinones by Transition-Metal-Free Direct Aerobic Oxidative Cascade Annulation of Alcohols with o-Aminoarylnitriles.
A mild and atom-economic method was developed for direct and efficient synthesis of quinazolinones through a transition-metal… 
2018
2018
The Synthesis of Quinazolinones from Olefins, CO, and Amines over a Heterogeneous Ru-clusters/Ceria Catalyst.
Quinazolinones, an important class of heterocyclic compounds, have been widely used in pharmaceuticals because of their… 
Highly Cited
2015
Highly Cited
2015
Copper-catalyzed radical methylation/C-H amination/oxidation cascade for the synthesis of quinazolinones.
A copper-catalyzed radical methylation/sp(3) C-H amination/oxidation reaction for the facile synthesis of quinazolinone was… 
Highly Cited
2014
Highly Cited
2014
Metal-free oxidative synthesis of quinazolinones via dual amination of sp3 C-H bonds.
A novel metal-free synthesis of quinazolinones via dual amination of sp(3) C-H bonds was developed. The sp(3) carbon in… 
Highly Cited
2012
Highly Cited
2012
Synthesis of 3-substituted and 2,3-disubstituted quinazolinones via Cu-catalyzed aryl amidation.
CuI/4-hydroxy-L-proline catalyzed coupling of N-substituted o-bromobenzamides with formamide takes place at 80 °C, affording 3… 
Highly Cited
2011
Highly Cited
2011
Copper-catalyzed domino synthesis of quinazolinones via Ullmann-type coupling and aerobic oxidative C-H amidation.
An efficient copper-catalyzed approach to quinazolinone derivatives has been developed, and the protocol uses cheap and readily… 
Highly Cited
2010
Highly Cited
2010
One-step synthesis of quinazolino[3,2-a]quinazolinones via palladium-catalyzed domino addition/carboxamidation reactions.
A highly efficient palladium-catalyzed domino process has been developed for the synthesis of quinazolino[3,2-a]quinazolinones by… 
Highly Cited
2008
Highly Cited
2008
Quinazolinones and pyrido[3,4-d]pyrimidin-4-ones as orally active and specific matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis.
Quinazolinones 8 and pyrido[3,4-d]pyrimidin-4-ones 9 as orally active and specific matrix metalloproteinase-13 inhibitors were… 
Highly Cited
2006
Highly Cited
2006
Discovery of potent and selective PARP-1 and PARP-2 inhibitors: SBDD analysis via a combination of X-ray structural study and homology modeling.
Highly Cited
1982
Highly Cited
1982
A new class of heterocyclic serine protease inhibitors. Inhibition of human leukocyte elastase, porcine pancreatic elastase, cathepsin G, and bovine chymotrypsin A alpha with substituted…
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