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Discovery of benzimidazole derivatives as novel multi-target EGFR, VEGFR-2 and PDGFR kinase inhibitors.
Clustered patterns of species origins of nature-derived drugs and clues for future bioprospecting
Four lines of evidence from historical drug data, 13,548 marine natural products, 767 medicinal plants, and 19,721 bioactive natural products suggest that drugs are derived mostly from preexisting drug-productive families.
Drug cytotoxicity and signaling pathway analysis with three-dimensional tumor spheroids in a microwell-based microfluidic chip for drug screening.
The effect of survivin on multidrug resistance mediated by P-glycoprotein in MCF-7 and its adriamycin resistant cells.
- F. Liu, Zhenhua Xie, G. Cai, Yuyang Jiang
- Biology, MedicineBiological & pharmaceutical bulletin
- 1 December 2007
The results suggest that survivin might play a key role in MDR in the presence of P-glycoprotein, and this might represent a novel strategy for modulating M DR in cancer cells.
NEAT1 modulates herpes simplex virus-1 replication by regulating viral gene transcription
It is demonstrated that HSV-1 infection increases NEAT1 expression and paraspeckle formation in a STAT3-dependent manner, providing insight into the roles of lncRNAs in the epigenetic control of viral genes and into the function of Paraspeckles.
Pro-oncogene Pokemon promotes breast cancer progression by upregulating survivin expression
Pokemon promotes breast cancer progression by upregulating survivin expression and thus may be a potential target for the treatment of this malignancy.
Survivin transcription is associated with P-glycoprotein/MDR1 overexpression in the multidrug resistance of MCF-7 breast cancer cells.
- F. Liu, Shi-ying Liu, Shengnan He, Zhenhua Xie, Xuyu Zu, Yuyang Jiang
- Biology, MedicineOncology reports
- 1 May 2010
This study shows survivin transcription was associated with P-glycoprotein/MDR1 overexpression, PI3k/Akt pathway was involved in P- Glycop protein/ MDR1 associated survivin transcript activity in the multidrug resistant MCF-7 breast cancer cells.
LncRNA EPB41L4A-AS1 regulates glycolysis and glutaminolysis by mediating nucleolar translocation of HDAC2
Computer Aided Multi-target Drug Design, Multi-target Virtual Screening
Multi-target drugs against selective multiple targets improve therapeutic efficacy, safety and resistance profiles by collective regulations of a primary therapeutic target together with compensatory…
New benzimidazole acridine derivative induces human colon cancer cell apoptosis in vitro via the ROS-JNK signaling pathway
The new benzimidazole acridine derivative, 8m exerts anticancer activity against human colon cancer cells in vitro by inducing both intrinsic and extrinsic apoptosis pathways via the ROS-JNK1 pathway.