CAL 101

Known as: CAL-101, CAL101, Phosphoinositide-3 Kinase Delta Inhibitor CAL-101 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

2009-2017
051020092017

Papers overview

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Highly Cited
2014
Highly Cited
2014
In a phase 1 trial, idelalisib (GS-1101, CAL-101), a selective inhibitor of the lipid kinase PI3Kδ, was evaluated in 54 patients… (More)
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2012
2012
GS-1101 (CAL-101) is an oral PI3Kδ-specific inhibitor that has shown preclinical and clinical activity in non-Hodgkin lymphoma… (More)
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2012
2012
Stroma induces treatment resistance in chronic lymphocytic leukemia (CLL), possibly because of alterations in the BCL-2 family of… (More)
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2012
2012
Targeted therapy with imatinib has transformed the treatment of chronic myeloid leukemia (CML). Unlike CML, chronic lymphocytic… (More)
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Highly Cited
2011
Highly Cited
2011
In lymphocytes, the phosphoinositide 3'-kinase (PI3K) isoform p110δ (PI3Kδ) transmits signals from surface receptors, including… (More)
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Highly Cited
2011
Highly Cited
2011
Phosphatidylinositol-3-kinase p110δ serves as a central integration point for signaling from cell surface receptors known to… (More)
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2011
2011
6631 Background: The class I phosphatidylinositol 3-kinases (PI3Ks) regulate cellular functions relevant to oncogenesis… (More)
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Highly Cited
2010
Highly Cited
2010
Targeted therapy with imatinib in chronic myeloid leukemia (CML) prompted a new treatment paradigm. Unlike CML, chronic… (More)
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Highly Cited
2010
Highly Cited
2010
In this study, we demonstrate expression and examined the biologic sequelae of PI3K/p110delta signaling in multiple myeloma (MM… (More)
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2009
2009
3543 Background: The class I PI3Ks regulate a variety of cellular functions relevant to oncogenesis, including metabolism… (More)
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