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grepafloxacin

Known as: (+--)-1-cyclopropyl-6-fluoro-1,4-dihydro-5-methyl-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid, 3-quinolinecarboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-5-methyl-7-(3-methyl-1-piperazinyl)-4-oxo-, (RS)-1-cyclopropyl-6-fluoro-5-methyl-7-(3-methylpiperazin-1-yl)- 4-oxo-quinoline- 3-carboxylic acid 
National Institutes of Health

Related topics

Related topics

6 relations

Broader (4)

Anti-Bacterial AgentsFluoroquinolonesPiperazinesTopoisomerase II Inhibitors
Grepafloxacin:Susc:Pt:Isolate:OrdQn:Gradient strip

Narrower (1)

OPC 17116

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2004
Highly Cited
2004
Differential Involvement of Multidrug Resistance-Associated Protein 1 and P-Glycoprotein in Tissue Distribution and Excretion of Grepafloxacin in Mice
The involvement of multidrug resistance-associated protein 1 (Mrp1) and P-glycoprotein (mdr1) in the tissue distribution and… 
Review
2003
Review
2003
Five-year analysis of Haemophilus influenzae isolates with reduced susceptibility to fluoroquinolones: prevalence results from the SENTRY antimicrobial surveillance program.
Highly Cited
2002
Highly Cited
2002
Pharmacokinetic role of P-glycoprotein in oral bioavailability and intestinal secretion of grepafloxacin in vivo.
The purpose of this study was to clarify the contribution of P-glycoprotein to the bioavailability and intestinal secretion of… 
2002
2002
Antimicrobial resistance trends in community-acquired respiratory tract pathogens in the Western Pacific Region and South Africa: report from the SENTRY antimicrobial surveillance program, (1998-1999…
Highly Cited
1999
Highly Cited
1999
In-vitro activity of grepafloxacin, a new fluoroquinolone, against mycoplasmas.
The in-vitro activity of grepafloxacin, a new oral fluoroquinolone antibiotic, was compared with those of three other… 
Review
1997
Review
1997
Antibacterial activity of grepafloxacin.
Grepafloxacin has an extremely broad spectrum of activity. Its activity against Gram-positive bacteria exceeds that of currently… 
Review
1997
Review
1997
Safety profile of grepafloxacin compared with other fluoroquinolones.
Preclinical investigations with grepafloxacin showed that its toxicological profile is similar to that of other fluoroquinolones… 
1997
1997
The in-vitro activity of grepafloxacin against Chlamydia spp., Mycoplasma spp., Ureaplasma urealyticum and Legionella spp.
The activity of grepafloxacin, a new orally active fluoroquinolone, was compared with the activities of ofloxacin, clarithromycin… 
1996
1996
Tentative interpretive criteria for testing the susceptibility of Streptococcus pneumoniae to eight fluoroquinolones.
Review
1988
Review
1988
Safety Overview: Toxicity, Adverse Effects, and Drug Interactions
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