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gacyclidine

Known as: Piperidine, 1-(2-methyl-1-(2-thienyl)cyclohexyl)-, cis-, methyl-2-r-(piperidine-1-)-1-(thienyl-2)1-cyclohexene 
National Institutes of Health

Related topics

Related topics

5 relations

Broader (4)

CyclohexenesExcitatory Amino Acid AntagonistsNeuroprotective AgentsPiperidines

Narrower (1)

GK 11

Papers overview

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2002
2002
Re‐evaluation of phencyclidine low‐affinity or “non‐NMDA” binding sites
TCP and its derivative gacyclidine (± GK11) are high‐affinity non‐competitive antagonists of N‐methyl‐D‐aspartate (NMDA… 
2001
2001
Gacyclidine (Beaufour-Ipsen).
Beaufour-Ipsen is developing gacyclidine (GK-11) for the potential treatment of traumatic brain injury. Phase II clinical trials… 
Review
2001
Review
2001
Gacyclidine (Beaufour-Ipsen).
Beaufour-Ipsen is developing gacyclidine (GK-11) for the potential treatment of traumatic brain injury. Phase II clinical trials… 
2001
2001
Distribution of gacyclidine enantiomers after experimental spinal cord injury in rats: possible involvement of an active transport system.
The pharmacokinetics of gacyclidine enantiomers, a noncompetitive N-methyl-D-aspartate (NMDA) antagonist, were studied in plasma… 
2001
2001
Characterization of ‘non‐N‐methyl‐d‐Aspartate’ binding sites for gacyclidine enantiomers in the rat cerebellar and telencephalic structures
Gacyclidine is a non‐competitive NMDA receptor antagonist with potent neuroprotective properties. However, we have previously… 
2001
2001
Interaction of gacyclidine enantiomers with ‘non-NMDA’ binding sites in the rat central nervous system
2000
2000
Efficacy of a new neuroprotective agent, gacyclidine, in a model of rat spinal cord injury.
Prevention of the immediate excitotoxic phase occurring in response to spinal cord injury (SCI) is a major issue to reduce the… 
2000
2000
The novel non-competitive N-methyl-d-aspartate antagonist gacyclidine blocks the glutamate-induced release of hydroxyl radicals in the striatum under conditions in which dizocilpine does not. A…
2000
2000
Binding properties of [3H]gacyclidine in the rat central nervous system.
1999
1999
Sensitive gas chromatographic-mass spectrometric method for the determination of gacyclidine in rat plasma and spinal cord dialyzates.
A sensitive gas chromatographic-mass spectrometric (GC-MS) procedure is described for the selective determination of gacyclidine… 
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