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GK 11

Known as: GK-11, GK11 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

gacyclidine

Papers overview

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2013
2013
Gacyclidine improves the survival and reduces motor deficits in a mouse model of amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder typified by a massive loss of motor neurons with few… 
2010
2010
The use of Organotypic Hippocampal Slice Cultures to Evaluate Protection by Non-competitive NMDA Receptor Antagonists against Excitotoxicity
There is great interest in testing neuroprotectants which inhibit the neurodegeneration that results from excessive activation of… 
2007
2007
Comparison of the pharmacological properties of GK11 and MK801, two NMDA receptor antagonists: towards an explanation for the lack of intrinsic neurotoxicity of GK11
Over‐stimulation of NMDA receptors (NMDARs) is involved in many neurodegenerative disorders. Thus, developing safe NMDAR… 
2005
2005
Neuroprotection from soman-induced seizures in the rodent: evaluation with diffusion- and T2-weighted magnetic resonance imaging.
2000
2000
Essential Role for the Legionella pneumophila Rep Helicase Homologue in Intracellular Infection of Mammalian Cells
ABSTRACT We have previously isolated 32 mutants of Legionella pneumophila that are defective in the infection of mammalian cells… 
Review
1999
Review
1999
Review of the value of gacyclidine (GK-11) as adjuvant medication to conventional treatments of organophosphate poisoning: primate experiments mimicking various scenarios of military or terrorist…
Today, organophosphorus nerve agents are still considered as potential threats in both military or terrorism situations. These… 
1999
1999
Acute soman poisoning in primates neither pretreated nor receiving immediate therapy: value of gacyclidine (GK-11) in delayed medical support
Abstract Organophosphorus (OP) nerve agents are still used as warfare and terrorism compounds. Classical delayed treatment of… 
Highly Cited
1997
Highly Cited
1997
Nerve agent poisoning in primates: antilethal, anti-epileptic and neuroprotective effects of GK-11
Abstract Organophosphorus nerve agents are still in use today in warfare and as terrorism compounds. Classical emergency… 
1997
1997
GK 11: promising additional neuroprotective therapy for organophosphate poisoning.
Recent experiments with primates have demonstrated that treatment with atropine/pralidoxime/diazepam, even if administered… 
1997
1997
Morphological and morphometric analysis of serotonin-containing neurons in primary dissociated cultures of human rhombencephalon: a study of development.
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