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fumagillol

Known as: 1-Oxaspiro(2.5)octan-6-ol, 5-methoxy-4-(2-methyl-3-(3-methyl-2-butenyl)oxiranyl)-, (3R-(3alpha,4alpha(2R*,3R*),5beta,6beta))- 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (2)

CyclohexanesSesquiterpenes

Papers overview

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2014
2014
Remodeling of Fumagillol: Discovery of an Oxygen-Directed Oxidative Mannich Reaction
An efficient, two-step construction of highly complex alkaloid-like compounds from the natural product fumagillol is described… 
2010
2010
Spectroscopic detection of pharmaceutical compounds from an aflatoxigenic strain of Aspergillus parasiticus.
2010
2010
In vivo evaluation of microspheres containing the angiogenesis inhibitor, TNP-470, and the metastasis suppression with liver metastatic model implanted neuroblastoma.
2009
2009
Carbamate analogues of fumagillin as potent, targeted inhibitors of methionine aminopeptidase-2.
Inhibition of methionine aminopeptidase-2 (MetAP2) represents a novel approach to antiangiogenic therapy. We describe the… 
2006
2006
Concise enantio- and diastereoselective total syntheses of fumagillol, RK-805, FR65814, ovalicin, and 5-demethylovalicin.
2001
2001
A new, ring closing metathesis-based synthesis of (-)-fumagillol.
[reaction: see text]. A new strategy to access the fumagillin/fumagillol skeleton is proposed. An Evans aldolization and a RCM… 
2000
2000
Efficacy of antiangiogenic therapy with TNP-470 in superficial and invasive bladder cancer models in mice.
1999
1999
A Concise Synthesis of Fumagillol.
A 13-step synthesis of (±)-fumagillol (1), the direct precursor of the potent angiogenesis inhibitors TNP-470 and fumagillin… 
Review
1996
Review
1996
Section Review Oncologic, Endocrine & Metabolic: Angiogenesis inhibition as a drug target for disease: an update
Angiogenesis is required for the development of many proliferative diseases, including granulomatous disease, such as rheumatoid… 
1994
1994
Angiogenesis Inhibitor O-(Chloroacetyl-carbamoyl) fumagillol (TNP-470) Inhibits Tumor Angiogenesis, Growth and Spontaneous Metastasis of MKL-4 Human Breast Cancer Cells in Female Athymic Nude Mice.
Accumulated knwoledge regarding the important roles played by angiogenesis in solid tumor growth and metastasis has prompted the… 
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