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fumagillol

Known as: 1-Oxaspiro(2.5)octan-6-ol, 5-methoxy-4-(2-methyl-3-(3-methyl-2-butenyl)oxiranyl)-, (3R-(3alpha,4alpha(2R*,3R*),5beta,6beta))- 
National Institutes of Health

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2 relations

Broader (2)

CyclohexanesSesquiterpenes

Papers overview

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2014
2014
Remodeling of Fumagillol: Discovery of an Oxygen-Directed Oxidative Mannich Reaction
An efficient, two-step construction of highly complex alkaloid-like compounds from the natural product fumagillol is described… 
2009
2009
Carbamate analogues of fumagillin as potent, targeted inhibitors of methionine aminopeptidase-2.
Inhibition of methionine aminopeptidase-2 (MetAP2) represents a novel approach to antiangiogenic therapy. We describe the… 
2004
2004
Urinary Matrix Metalloproteinases and their Endogenous Inhibitors Predict Hepatic Regeneration after Murine Partial Hepatectomy
Background. Matrix metalloproteinases (MMPs) play a key role in extracellular matrix remodeling events associated with hepatic… 
2004
2004
Composition for obesity treatment comprising fumagillol derivatives
The present invention is O - (4-methoxy-cinnamoyl) Puma jilrol, O - (3,4,5- trimethoxy-cinnamoyl) Puma jilrol, O - (4-methoxy… 
2001
2001
A new, ring closing metathesis-based synthesis of (-)-fumagillol.
[reaction: see text]. A new strategy to access the fumagillin/fumagillol skeleton is proposed. An Evans aldolization and a RCM… 
2001
2001
The inhibitory effects of TNP470 on tumour growth of head and neck carcinoma cell producing interleukin-8
The anti-tumour effect of the angiogenic inhibitor TNP470, σ-(chloro-acetyl-carbamoyl) fumagillol, a synthetic analogue of… 
1999
1999
A Concise Synthesis of Fumagillol.
A 13-step synthesis of (±)-fumagillol (1), the direct precursor of the potent angiogenesis inhibitors TNP-470 and fumagillin… 
1999
1999
Delay in administration of CDDP until completion of AGM-1470 treatment enhances antimetastatic and antitumor effects
The efficacy of cis-diammine dichloroplatinum (CDDP) therapy in combination with continuous administration of angiogenesis… 
1994
1994
Angiogenesis inhibitorO-(chloroacetyl-carbamoyl) fumagillol (TNP-470) inhibits tumor angiogenesis, growth and spontaneous metastasis of MKL- 4 human breast cancer cells in female athymic nude mice
Accumulated knowledge regarding the important roles played by angiogenesis in solid tumor growth and metastasis has prompted the… 
1994
1994
Angiogenesis Inhibitor O-(Chloroacetyl-carbamoyl) fumagillol (TNP-470) Inhibits Tumor Angiogenesis, Growth and Spontaneous Metastasis of MKL-4 Human Breast Cancer Cells in Female Athymic Nude Mice.
Accumulated knwoledge regarding the important roles played by angiogenesis in solid tumor growth and metastasis has prompted the… 
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