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WIN 64821, a new competitive antagonist to substance P, isolated from an Aspergillus species: structure determination and solution conformation
Two new diketopiperazine dimers, WIN 64821 (1a) and WIN 64745 12), were isolated from an Aspergillus culture originally isolated from soil and their structures established on the basis of chemicalExpand
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Ultrasound-promoted cycloadditions in the synthesis of Salvia miltiorrhiza abietanoid o-quinones
The ultrasound-promoted Diels-Alder reaction of 3-methyl-4,5-benzofurandione with appropriately substituted vinylcyclohexenes has led to the synthesis of tanshinone IIA, nortanshinone, tanshindiol B,Expand
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Epi-danshenspiroketallactone from Salvia miltiorrhiza
Abstract The structure of a new abietanoid pigment from the Chinese traditional medicine Dan-shen, Salvia miltiorrhiza, was isolated and its structure determined by NMR spectroscopy.
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Core as a Novel Viral Target for Hepatitis C Drugs
Hepatitis C virus (HCV) infects over 130 million people worldwide and is a major cause of liver disease. No vaccine is available. Novel specific drugs for HCV are urgently required, since theExpand
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A time-resolved fluorescence-resonance energy transfer assay for identifying inhibitors of hepatitis C virus core dimerization.
Binding of hepatitis C virus (HCV) RNA to core, the capsid protein, results in the formation of the nucleocapsid, the first step in the assembly of the viral particle. A novel assay was developed toExpand
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New Small Molecule Inhibitors of Hepatitis C Virus.
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Remodeling of the Natural Product Fumagillol Employing a Reaction Discovery Approach
In the search for new biologically active molecules, diversity-oriented synthetic strategies break through the limitation of traditional library synthesis by sampling new chemical space. Many naturalExpand
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