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WIN 64821, a new competitive antagonist to substance P, isolated from an Aspergillus species: structure determination and solution conformation
Two new diketopiperazine dimers, WIN 64821 (1a) and WIN 64745 12), were isolated from an Aspergillus culture originally isolated from soil and their structures established on the basis of chemical… Expand
Diosgenin-bearing, molluscicidal saponins from Allium vineale: an NMR approach for the structural assignment of oligosaccharide units
Ultrasound-promoted Diels-Alder reactions: syntheses of tanshinone IIA, nortanshinone, and (.+-.)-tanshindiol B
Ultrasound-promoted cycloadditions in the synthesis of Salvia miltiorrhiza abietanoid o-quinones
The ultrasound-promoted Diels-Alder reaction of 3-methyl-4,5-benzofurandione with appropriately substituted vinylcyclohexenes has led to the synthesis of tanshinone IIA, nortanshinone, tanshindiol B,… Expand
Epi-danshenspiroketallactone from Salvia miltiorrhiza
Abstract The structure of a new abietanoid pigment from the Chinese traditional medicine Dan-shen, Salvia miltiorrhiza, was isolated and its structure determined by NMR spectroscopy.
Core as a Novel Viral Target for Hepatitis C Drugs
- A. D. Strosberg, Smitha Kota, Virginia Takahashi, J. Snyder, Guillaume Mousseau
- Biology, Medicine
- 1 August 2010
Hepatitis C virus (HCV) infects over 130 million people worldwide and is a major cause of liver disease. No vaccine is available. Novel specific drugs for HCV are urgently required, since the… Expand
A time-resolved fluorescence-resonance energy transfer assay for identifying inhibitors of hepatitis C virus core dimerization.
- Smitha Kota, L. Scampavia, +6 authors A. D. Strosberg
- Chemistry, Medicine
- Assay and drug development technologies
- 24 February 2010
Binding of hepatitis C virus (HCV) RNA to core, the capsid protein, results in the formation of the nucleocapsid, the first step in the assembly of the viral particle. A novel assay was developed to… Expand
New Small Molecule Inhibitors of Hepatitis C Virus.
Intramolecular Rhodium‐Catalyzed [2 + 2 + 2] Cyclizations of Diynes with Enones.
Remodeling of the Natural Product Fumagillol Employing a Reaction Discovery Approach
- Bradley R. Balthaser, Meghan Maloney, A. B. Beeler, J. Porco, J. Snyder
- Chemistry, Medicine
- Nature Chemistry
- 11 October 2011
In the search for new biologically active molecules, diversity-oriented synthetic strategies break through the limitation of traditional library synthesis by sampling new chemical space. Many natural… Expand