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RNA-Methylation-Dependent RNA Processing Controls the Speed of the Circadian Clock
TLDR
It is reported that inhibition of transmethylation reactions elongates the circadian period and methylation inhibition causes widespread changes in the transcription of the RNA processing machinery, associated with m(6)A-RNA methylation. Expand
Innovative preparation of curcumin for improved oral bioavailability.
TLDR
THERACURMIN exhibited an inhibitory action against alcohol intoxication after drinking in humans, as evidenced by the reduced acetaldehyde concentration of the blood, and shows a much higher bioavailability than currently available preparations. Expand
UCHL1 provides diagnostic and antimetastatic strategies due to its deubiquitinating effect on HIF-1α
TLDR
It is shown that Ubiquitin C-terminal hydrolase-L1 (UCHL1) abrogates the von Hippel–Lindau-mediated ubiquitination of Hif-1α, the regulatory subunit of HIF-1, and consequently promotes metastasis. Expand
Biotransformation of the Mycotoxin, Zearalenone, to a Non-estrogenic Compound by a Fungal Strain of Clonostachys sp.
TLDR
It is found that Clonostachys rosea IFO 7063 was effectively capable of converting zearalenone to cleavage product (2), 1-(3,5-dihydroxyphenyl)-10′-hydroxy-1′E-undecene-6′-one, which did not show potent estrogenic activity like that of 17β-estradiol in the human breast cancer MCF-7 cell proliferation assay. Expand
A novel lactonohydrolase responsible for the detoxification of zearalenone: enzyme purification and gene cloning.
TLDR
Zearalenone (ZEN) is converted into a far less oestrogenic product by incubation with Clonostachys rosea IFO 7063 and the entire coding region of the gene is cloned by PCR techniques, suggesting Zhd101 could be a promising genetic resource for in planta detoxification of the mycotoxin in important crops. Expand
Epolactaene binds human Hsp60 Cys442 resulting in the inhibition of chaperone activity.
TLDR
The identification of the binding proteins of epolactaene/ETB, and the results of the investigation into its inhibitory mechanism indicate that this cysteine residue is alkylated by ETB, leading to Hsp60 inactivation. Expand
Dephostatin, a novel protein tyrosine phosphatase inhibitor produced by Streptomyces. I. Taxonomy, isolation, and characterization.
TLDR
A novel inhibitor of protein tyrosine phosphatase, dephostatin, was isolated from the culture broth of a strain of Streptomyces and inhibited the growth of Jurkat cells. Expand
Caspase-mediated activation of a 36-kDa myelin basic protein kinase during anticancer drug-induced apoptosis.
TLDR
Results indicate that p36 MBP kinase activation is downstream of the activation of Z-Asp-CH2-DCB-sensitive caspases, and reactive oxygen species could be included in the apoptotic events. Expand
Novel mammalian cell cycle inhibitors, tryprostatins A, B and other diketopiperazines produced by Aspergillus fumigatus. I. Taxonomy, fermentation, isolation and biological properties.
TLDR
The diketopiperazines showed an inhibitory activity on the cell cycle progression of mouse tsFT210 cells in the M phase with the MIC values of 16.4 microM and 12.2 microM, respectively. Expand
Marine antifungal theonellamides target 3beta-hydroxysterol to activate Rho1 signaling.
TLDR
Theonellamides, bicyclic peptides derived from marine sponges, represent a new class of sterol-binding molecules that induce membrane damage and activate Rho1-mediated 1,3-beta-D-glucan synthesis. Expand
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