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Epolactaene binds human Hsp60 Cys442 resulting in the inhibition of chaperone activity.
- Y. Nagumo, H. Kakeya, M. Shoji, Y. Hayashi, N. Dohmae, H. Osada
- Chemistry, Medicine
- The Biochemical journal
- 1 May 2005
The identification of the binding proteins of epolactaene/ETB, and the results of the investigation into its inhibitory mechanism indicate that this cysteine residue is alkylated by ETB, leading to Hsp60 inactivation. Expand
Direct proline catalyzed asymmetric α-aminooxylation of aldehydes
Abstract The direct catalytic enantioselective α-aminooxylation of aldehydes has been developed using nitrosobenzene as the oxygen source and l -proline as catalyst, affording versatile… Expand
A Novel Adenine Nucleotide Translocase Inhibitor, MT-21, Induces Cytochrome c Release by a Mitochondrial Permeability Transition-independent Mechanism*
Although ANT resides in the mitochondrial inner membrane, specific ANT inhibitors can induce cytochrome c release without having an effect on inner membrane permeability, suggesting that MT-21 can be a powerful tool for studying the mechanism of PT-independent cytochromec release from mitochondria. Expand
STEREOSELECTIVE SYNTHESIS OF α-RIBONUCLEOSIDES FROM 1-HYDROXY SUGARS BY USING 2-FLUOROPYRIDINIUM TOSYLATE
A novel method for the preparation of α-ribonucleosides was developed by the use of 2-fluoro-1-methylpyridinium tosylate as a condensing reagent. Various α-ribonucleosides were synthesized from… Expand
Organocatalyzed Michael Addition of Aldehydes to Nitro Alkenes – Generally Accepted Mechanism Revisited and Revised
The amine-catalyzed enantioselective Michael addition of aldehydes to nitro alkenes (Scheme 1) is known to be acid-catalyzed (Fig. 1). A mechanistic investigation of this reaction, catalyzed by… Expand
High-yielding synthesis of the anti-influenza neuramidase inhibitor (-)-oseltamivir by three "one-pot" operations.
A remarkably short and high-yielding asymmetric total synthesis of (-)-oseltamivir takes advantage of organocatalysis and single-pot domino operations. Expand
Highly diastereo- and enantioselective direct aldol reactions in water.
A diarylprolinol in an asymmetric, catalytic, and direct crossed-aldol reaction of acetaldehyde.
Diphenylprolinol silyl ether catalysis in an asymmetric formal carbo [3 + 3] cycloaddition reaction via a domino Michael/Knoevenagel condensation.
Diphenylprolinol silyl ether was found to catalyze the formal carbo [3 + 3] cycloaddition reaction through the domino reaction via the Michael reaction, followed by Knoevenagel condensation of the… Expand
A Highly Active 4‐Siloxyproline Catalyst for Asymmetric Synthesis
trans-4-tert-Butyldimethylsiloxy-L-proline displays a greater catalytic activity than the parent proline without compromising the enantioselectivity, which widens the substrate scope in the… Expand