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fosbretabulin

Known as: 1-(3,4,5-Trimethoxyphenyl)-2-(3'-hydroxy-4'-methoxyphenyl)ethene, Combretastatin A-4 Phosphate, Combretastatin A-4 
A water-soluble prodrug derived from the African bush willow (Combretum caffrum) with antineoplastic activity. Fosbretabulin is dephosphorylated to… 
National Institutes of Health

Related topics

Related topics

10 relations

Broader (2)

Antineoplastic Agents, PhytogenicStilbenes

Narrower (3)

CRC 87-09combretastatin A-4 disodium phosphatecombretastatin A4 phosphate
Fosbretabulin TromethamineMicrotubule ProcessNCIt Antineoplastic Agent Terminologydeoxycombretastatin A-4

Papers overview

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Highly Cited
2010
Highly Cited
2010
Design, synthesis, and biological evaluations of 2,5-diaryl-2,3-dihydro-1,3,4-oxadiazoline analogs of combretastatin-A4.
A total of 24 novel 2,5-diaryl-1,3,4-oxadiazoline analogs of combretastatin A-4 (CA-4, 1) were designed, synthesized, and… 
Highly Cited
2010
Highly Cited
2010
Self-assembled core-shell vascular-targeted nanocapsules for temporal antivasculature and anticancer activities.
A biocompatible core-shell nanocapsule is fabricated to target tumor vascular endothelial cells where it releases anti… 
Highly Cited
2008
Highly Cited
2008
Novel A-ring and B-ring modified combretastatin A-4 (CA-4) analogues endowed with interesting cytotoxic activity.
A novel class of combretastatins, modified at A-ring or both A- and B-rings, mainly by replacement with benzofuran or benzo[b… 
Highly Cited
2006
Highly Cited
2006
Combretastatin CA-4 and combretastatin derivative induce mitotic catastrophe dependent on spindle checkpoint and caspase-3 activation in non-small cell lung cancer cells
Combretastatin A-4 (CA-4), a natural stilbenoid isolated from Combretum caffrum, is a new vascular targeting agent (VTA) known… 
Highly Cited
2006
Highly Cited
2006
Synthesis and biological evaluation of 2-amino-3-(3',4',5'-trimethoxybenzoyl)-5-aryl thiophenes as a new class of potent antitubulin agents.
A new series of compounds in which the 2-amino-5-chlorophenyl ring of phenstatin analogue 7 was replaced with a 2-amino-5-aryl… 
Highly Cited
2005
Highly Cited
2005
Synthesis and cytotoxicity of epoxide and pyrazole analogs of the combretastatins.
Highly Cited
1999
Highly Cited
1999
Evaluation of Antivascular and Antimitotic Effects of Tubulin Binding Agents in Solid Tumor Therapy
Tubulin binding agents (TBAs) reduce tumor perfusion and inhibit mitosis of tumor cells in solid tumors, but it is not clear… 
Highly Cited
1999
Highly Cited
1999
A Novel Combretastatin A‐4 Derivative, AC‐7700, Shows Marked Antitumor Activity against Advanced Solid Tumors and Orthotopically Transplanted Tumors
AC‐7700, a novel combretastatin A‐4 derivative, suppresses the growth of solid tumors by inhibiting tumor perfusion. We evaluated… 
Highly Cited
1998
Highly Cited
1998
Induction of apoptosis in proliferating human endothelial cells by the tumor-specific antiangiogenesis agent combretastatin A-4.
The antiangiogenic, tubulin-binding drug combretastatin A-4 exhibits a selective toxicity for proliferating endothelial cells in… 
Highly Cited
1996
Highly Cited
1996
Computational and molecular modeling evaluation of the structural basis for tubulin polymerization inhibition by colchicine site agents.
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