fosbretabulin

Known as: 1-(3,4,5-Trimethoxyphenyl)-2-(3'-hydroxy-4'-methoxyphenyl)ethene, Combretastatin A-4 Phosphate, Combretastatin A-4 
A water-soluble prodrug derived from the African bush willow (Combretum caffrum) with antineoplastic activity. Fosbretabulin is dephosphorylated to… (More)
National Institutes of Health

Papers overview

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2014
2014
BACKGROUND Anaplastic thyroid cancer (ATC), a rare highly vascularized tumor, has a dismal outcome. We conducted an open-label… (More)
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Review
2009
Review
2009
Vascular disrupting agents (VDAs) are a relatively new group of 'vascular targeting' agents that exhibit selective activity… (More)
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Highly Cited
2008
Highly Cited
2008
Cancer is a major public health burden in both developed and developing countries. Plant derived agents are being used for the… (More)
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Highly Cited
2001
Highly Cited
2001
The tumor vascular effects of the tubulin destabilizing agent disodium combretastatinA-4 3-O-phosphate (CA-4-P) were investigated… (More)
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Highly Cited
1997
Highly Cited
1997
Selective induction of vascular damage within tumors represents an emerging approach to cancer treatment. Histological studies… (More)
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Highly Cited
1995
Highly Cited
1995
A series of stilbenes, based on combretastatin A-4, were synthesised. A structure-activity study was carried out to characterise… (More)
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1995
1995
The antineoplastic constituents of Combretum caffrum (Eckl. and Zeyh) Kuntze (Combretaceae family), a species indigenous to South… (More)
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Highly Cited
1994
Highly Cited
1994
A metabolite of estradiol, 2-methoxyestradiol (2ME), inhibits angiogenesis in the chicken embryo chorioallantoic membrane assay… (More)
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Highly Cited
1989
Highly Cited
1989
Combretastatin A-4 (CS-A4), 3,4,5-trimethoxy-3'-hydroxy-4'-methoxy-(Z)-stilbene, and combretastatin A-2 (CS-A2), 3,4… (More)
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1988
1988
Combretastatin, an antineoplastic and antimitotic agent, was isolated from the bark of Combretum caffrum [Can. J. Chem. 60: 1374… (More)
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