combretastatin A4 phosphate

Known as: Combretastatin A4 Prodrug 
A water-soluble prodrug derived from the African bush willow (Combretum caffrum) with tumor vascular-targeting activity. In vivo, combretastatin A4… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1999-2018
024619992018

Papers overview

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Highly Cited
2011
Highly Cited
2011
Vascular-disrupting agents (VDAs) such as combretastatin A4 phosphate (CA4P) selectively disrupt blood vessels in tumors and… (More)
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Highly Cited
2009
Highly Cited
2009
The purpose was to determine the reproducibility of apparent diffusion coefficient (ADC) measurements in a two-centre phase I… (More)
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2005
2005
PURPOSE To evaluate the effect of the vascular targeting agent, combretastatin A4 phosphate, on tumor oxygenation compared with… (More)
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2004
2004
PURPOSE Combretastatin A4 phosphate (CA4P) and its structural analog, combretastatin A1 phosphate (CA1P), are soluble prodrugs… (More)
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Highly Cited
2003
Highly Cited
2003
PURPOSE A phase I trial was performed with combretastatin A4 phosphate (CA4P), a novel tubulin-binding agent that has been shown… (More)
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Highly Cited
2003
Highly Cited
2003
PURPOSE Clinical evaluation of novel agents that target tumor blood vessels requires pharmacodynamic end points that measure… (More)
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Highly Cited
2003
Highly Cited
2003
PURPOSE Combretastatin A4 (CA4) phosphate (CA4P) inhibits microtubule polymerization and is toxic to proliferating endothelial… (More)
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2002
2002
Anaplastic thyroid carcinoma (ATC) is a fatal malignancy the clinical outcome of which is unaltered by current therapeutic… (More)
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2001
2001
The acute effects of the antivascular drug, combretastatin A4 phosphate, on tumor energy status and perfusion were assessed using… (More)
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Highly Cited
1999
Highly Cited
1999
Combretastatin A4 phosphate has recently been identified by us as an agent which can selectively damage tumour neovasculature. In… (More)
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