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combretastatin A-4 disodium phosphate

Known as: CA4P, Combretastatin A4 Disodium Phosphate, Fosbretabulin Disodium 
The disodium salt of a water-soluble phosphate derivative of a natural stilbenoid phenol derived from the African bush willow (Combretum caffrum… 
National Institutes of Health

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Fosbretabulin TromethamineMicrotubule ProcessNCIt Antineoplastic Agent Terminologycombretastatin A4 phosphate

Papers overview

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2013
2013
Abstract 1688: Autophagy inhibition enhances the antitumor effects of combretastatin A4 phosphate (CA4P).
Review
2012
Review
2012
Combretastatin A-4 phosphate affects tumor vessel volume and size distribution as assessed using magnetic resonance imaging based vessel size imaging
Purpose: Combretastatin A-4 disodium phosphate (CA4P) is a promising vascular disrupting agent in clinical trials. As CA4P acts… 
Review
2010
Review
2010
MR-Elastography , a new biomarker of the tumor vascularization in a colon cancer mice model
Introduction Assessment and follow-up of neo-angiogenesis are major challenges to characterize the malignancy of tumors and to… 
2009
2009
Effect of vascular targeting on tumor vessel volume and size distribution
*Results: The maps of 0 and R showed heterogeneity and indicated different spatial distributions of the two parameters. Tumor… 
2008
2008
A phase I/II trial of radioimmunotherapy with (131)Iodine labelled A5B7 anti-CEA antibody (I-131-A5B7) in combination with Combretastatin-A4-Phosphate (CA4P) in advanced gastrointestinal carcinomas
14517 Background: In pre-clinical models the combination of radioimmunotherapy (RIT) with 131I-A5B7 and the vascular disruptive… 
2006
2006
Anti-angiogenic and antitumor activity of nanoparticle albumin bound (nab) thiocolchicine dimer (IDN5404) with a novel dual mechanism of action on Tubulin and Topoisomerase-1
3823 Background: IDN5404 is a novel thiocolchicine dimer with microtubule activity similar to colchicine and topo-I inhibitory… 
2005
2005
Structure-activity relationships and thermodynamics of combretastatin A-4 and A-1 derivatives as potential inhibitors of tubulin polymerization.
2005
2005
Multiple DCEMRI parameters detect necrosis induced by clinically equivalent acute doses of ZD6126 in Hras5 subcutaneous tumours in athymic rat
5demonstrated a dose dependent reduction in both enhancing fraction and R2* associated with correlative scores of tumour necrosis… 
2002
2002
Combretastatin-A 4 Prodrug Induces Mitotic Catastrophe in Chronic Lymphocytic Leukemia Cell Line Independent of Caspase Activation and Poly ( ADP-ribose ) Polymerase Cleavage 1
We have previously reported that combretastatin-A4 prodrug (CA4P), an antitubulin/antiangiogenic agent isolated from the South… 
2001
2001
Combretastatin A 4 Prodrug Study of Effect on the Growth and the Microvasculature of Colorectal Liver Metastases in a Murine Model 1
Combretastatin A4P (CA4P) is a prodrug that, in active form, binds to tubulin microtubules of capillary endothelial cells…