Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018
- L. Galluzzi, I. Vitale, G. Kroemer
- BiologyCell Death and Differentiation
- 23 January 2018
An updated classification of cell death subroutines focusing on mechanistic and essential aspects of the process is proposed, and the utility of neologisms that refer to highly specialized instances of these processes are discussed.
Molecular mechanisms of cisplatin resistance
- L. Galluzzi, L. Senovilla, G. Kroemer
- Biology, ChemistryOncogene
- 12 April 2012
A systematic discussion of the mechanisms that account for the cisplatin-resistant phenotype of tumor cells are described and the development of chemosensitization strategies constitute a goal with important clinical implications.
Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012
- L. Galluzzi, I. Vitale, G. Kroemer
- BiologyCell Death and Differentiation
- 2012
A functional classification of cell death subroutines is proposed that applies to both in vitro and in vivo settings and includes extrinsic apoptosis, caspase-dependent or -independent intrinsic programmed cell death, regulated necrosis, autophagic cell death and mitotic catastrophe.
Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes
- L. Galluzzi, S. Aaronson, G. Kroemer
- BiologyCell Death and Differentiation
- 17 April 2009
A nonexhaustive comparison of methods to detect cell death with apoptotic or nonapoptotic morphologies, their advantages and pitfalls is provided and the importance of performing multiple, methodologically unrelated assays to quantify dying and dead cells is emphasized.
Cell death modalities: classification and pathophysiological implications
- L. Galluzzi, M. Maiuri, G. Kroemer
- BiologyCell Death and Differentiation
- 13 April 2007
This review will synthetically and critically enumerate the current classifications of cell death, laying special emphasis on the link between the morphological, biochemical and pathophysiological characteristics of different cell death modalities.
Regulation of autophagy by cytoplasmic p53
- E. Tasdemir, M. Maiuri, G. Kroemer
- Biology, ChemistryNature Cell Biology
- 4 May 2008
Evidence is provided of a key signalling pathway that links autophagy to the cancer-associated dysregulation of p53, which improved the survival of p 53-deficient cancer cells under conditions of hypoxia and nutrient depletion, allowing them to maintain high ATP levels.
Consensus guidelines for the detection of immunogenic cell death
- O. Kepp, L. Senovilla, L. Galluzzi
- BiologyOncoimmunology
- 2 September 2014
Strategies conceived to detect surrogate markers of ICD in vitro and to screen large chemical libraries for putative I CD inducers are outlined, based on a high-content, high-throughput platform that was recently developed.
Essential versus accessory aspects of cell death: recommendations of the NCCD 2015
- L. Galluzzi, J. M. Bravo-San Pedro, G. Kroemer
- BiologyCell Death and Differentiation
- 19 September 2014
The Nomenclature Committee on Cell Death formulates a set of recommendations to help scientists and researchers to discriminate between essential and accessory aspects of cell death.
Cancer cell–autonomous contribution of type I interferon signaling to the efficacy of chemotherapy
- A. Sistigu, T. Yamazaki, L. Zitvogel
- Biology, MedicineNature Network Boston
- 26 October 2014
The data suggest that anthracycline-mediated immune responses mimic those induced by viral pathogens, and it is surmised that such 'viral mimicry' constitutes a hallmark of successful chemotherapy.
Macrophages and Metabolism in the Tumor Microenvironment.
- I. Vitale, G. Manic, L. Coussens, G. Kroemer, L. Galluzzi
- Biology, MedicineCell Metabolism
- 1 July 2019
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