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Chromatin and microtubule organization during premeiotic, meiotic and early postmeiotic stages of Drosophila melanogaster spermatogenesis.
TLDR
By means of bromo-deoxyuridine incorporation experiments, it is demonstrated that premeiotic DNA synthesis occurs very early during spermatocyte growth and meiotic divisions. Expand
Heparanase-mediated Loss of Nuclear Syndecan-1 Enhances Histone Acetyltransferase (HAT) Activity to Promote Expression of Genes That Drive an Aggressive Tumor Phenotype*
TLDR
A novel mechanistic pathway driven by heparanase expression is revealed, which leads to decreased nuclear syndecan-1, increased HAT activity, and up-regulation of transcription of multiple genes that drive an aggressive tumor phenotype. Expand
Y chromosome loops in Drosophila melanogaster.
TLDR
Primary spermatocyte nuclei of fixed testes of Drosophila melanogaster exhibit three large clusters of thread-like structures, each consisting of two long, continuous, loop-shaped filaments, which suggest that each loop is an integral part of a different fertility factor, representing the cytological manifestation of its activity in primary sperMatocytes. Expand
SST0001, a Chemically Modified Heparin, Inhibits Myeloma Growth and Angiogenesis via Disruption of the Heparanase/Syndecan-1 Axis
TLDR
These results provide mechanistic insight into the antitumor action of SST0001 and validate its use as a novel therapeutic tool for treating multiple myeloma. Expand
Modulation of the Heparanase-inhibiting Activity of Heparin through Selective Desulfation, Graded N-Acetylation, and Glycol Splitting*
TLDR
The combination of high inhibition of heparanase and low release/potentiation of ECM-bound growth factor indicates that N-acetylated, glycol-split heparins are potential antiangiogenic and antimetastatic agents that are more effective than their counterparts with unmodified backbones. Expand
Heparanase Is Essential for the Development of Diabetic Nephropathy in Mice
TLDR
The results collectively underscore the crucial role of heparanase in the pathogenesis of DN and its potential as a highly relevant target for therapeutic interventions in patients with DN. Expand
Significance of Heparanase in Cancer and Inflammation
TLDR
Combining radiotherapy with heparanase inhibition is an effective strategy to prevent tumor resistance and dissemination in IR-treated pancreatic cancer patients, and accumulating evidence indicate that peptides derived from human heParanase elicit a potent anti-tumor immune response, suggesting that he paranase represents a promising target antigen for immunotherapeutic approaches against a broad variety of tumours. Expand
Paclitaxel and Cisplatin-induced neurotoxicity: a protective role of acetyl-L-carnitine.
TLDR
It is indicated that ALC is a specific protective agent for chemotherapy-induced neuropathy after cisplatin or paclitaxel treatment without showing any interference with the antitumor activity of the drugs. Expand
Acetyl-L-Carnitine prevents and reverts experimental chronic neurotoxicity induced by oxaliplatin, without altering its antitumor properties.
TLDR
ALC is effective in the prevention and treatment of chronic OHP-induced peripheral neurotoxicity in an experimental rat model and indicates that ALC does not interfere with the antitumor effects of OHP. Expand
Novel Camptothecin Analogue (Gimatecan)‐Containing Liposomes Prepared by the Ethanol Injection Method
TLDR
It is shown that liposomal drug formulations can be prepared in situ, by simply injecting a drug‐containing lipid(s) organic solution into an aqueous solution, and that the Gimatecan‐containing liposomes formulations were able to realize a delivery system of a water‐insoluble drug. Expand
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