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febrifugine
Known as:
3-(3-(3-hydroxy-2-piperidinyl)-2-oxopropyl)- 4(3H)-quinazolinone
National Institutes of Health
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Related topics
Related topics
3 relations
Broader (2)
Piperidines
Quinazolines
Narrower (1)
isofebrifugine
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2017
Highly Cited
2017
Halofuginone enhances the chemo‐sensitivity of cancer cells by suppressing NRF2 accumulation
Kouhei Tsuchida
,
Tadayuki Tsujita
,
+8 authors
Masayuki Yamamoto
Free Radical Biology & Medicine
2017
Corpus ID: 3498627
Highly Cited
2015
Highly Cited
2015
The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs
J. Herman
,
L. Pepper
,
+21 authors
Ralph Mazitschek
Science Translational Medicine
2015
Corpus ID: 11178047
The cytoplasmic prolyl-tRNA synthetase of Plasmodium falciparum is a dual-stage therapeutic target for drug development. An…
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Highly Cited
2015
Highly Cited
2015
Structure of Prolyl-tRNA Synthetase-Halofuginone Complex Provides Basis for Development of Drugs against Malaria and Toxoplasmosis.
V. Jain
,
M. Yogavel
,
+4 authors
Amit Sharma
Structure
2015
Corpus ID: 40427603
Highly Cited
2011
Highly Cited
2011
Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase
T. Keller
,
D. Zocco
,
+12 authors
M. Whitman
Nature Chemical Biology
2011
Corpus ID: 18612333
Febrifugine, one of the fifty fundamental herbs of traditional Chinese medicine, has been characterized for its therapeutic…
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Highly Cited
2010
Highly Cited
2010
Synthesis and evaluation of 4-quinazolinone compounds as potential antimalarial agents.
Shuren Zhu
,
Joseph Y. Wang
,
G. Chandrashekar
,
Erika L. Smith
,
Xianjun Liu
,
Yongsheng Zhang
European journal of medicinal chemistry
2010
Corpus ID: 27986382
Highly Cited
2010
Highly Cited
2010
Dihydroxylation of vinyl sulfones: stereoselective synthesis of (+)- and (-)-febrifugine and halofuginone.
Noel P. McLaughlin
,
P. Evans
Journal of Organic Chemistry
2010
Corpus ID: 207749546
The asymmetric dihydroxylation of amino-functionalized vinyl sulfone 19 has been used for the 3-step preparation of 3…
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Highly Cited
2006
Highly Cited
2006
Exploration of a new type of antimalarial compounds based on febrifugine.
H. Kikuchi
,
Keisuke Yamamoto
,
+5 authors
Y. Oshima
Journal of Medicinal Chemistry
2006
Corpus ID: 38507957
Febrifugine (1), a quinazoline alkaloid, isolated from Dichroa febrifuga roots, shows powerful antimalarial activity against…
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Highly Cited
2005
Highly Cited
2005
Antimalarial Activities and Therapeutic Properties of Febrifugine Analogs
Suping Jiang
,
Q. Zeng
,
+7 authors
Daohe Fang
Antimicrobial Agents and Chemotherapy
2005
Corpus ID: 1704066
ABSTRACT Febrifugine is the active principal isolated 50 years ago from the Chinese herb chang shan (Dichroa febrifuga Lour…
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Highly Cited
2002
Highly Cited
2002
Potent antimalarial febrifugine analogues against the plasmodium malaria parasite.
H. Kikuchi
,
H. Tasaka
,
+7 authors
Y. Oshima
Journal of Medicinal Chemistry
2002
Corpus ID: 20359591
Although febrifugine (1) and isofebrifugine (2), alkaloids isolated from roots of the Dichroa febrifuga plant, show powerful…
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Highly Cited
2001
Highly Cited
2001
The European Agency for the Evaluation of Medicinal Products Veterinary Medicines and Information Technology
2001
Corpus ID: 13035819
1. Cefapirin is a first generation semi-synthetic cefalosporin with a broad spectrum of activity against both gram-positive and…
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