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Antimalarial activity of methanolic extracts from plants used in Kenyan ethnomedicine and their interactions with chloroquine (CQ) against a CQ-tolerant rodent parasite, in mice.
Plants, which showed significant antimalarial activity including Vernonia lasiopus, Toddalia asiatica, Ficus sur, Rhamnus prinoides and RhamNus staddo warrant further evaluation in the search for novel antimalaria agents against drug-resistant malaria. Expand
Formation of antioxidants from (-)-epigallocatechin gallate in mild alkaline fluids, such as authentic intestinal juice and mouse plasma.
The oxidative dimerization of (-)-epigallocatechin gallate (EGCG), the major catechin of tea leaves (Camellia sinensis L.), in authentic intestinal juice and mouse plasma was investigated and are expected to contribute to in vivo antioxidative activities enhanced by tea drinking. Expand
Inhibitors of xanthine oxidase from the flowers and buds of Daphne genkwa.
Xanthine oxidase (XO) inhibitors were isolated from the flowers and buds of Daphne genkwa SIEB and were identified as genkwanin (1), apigenin (2), luteolin 7-methyl ether (3) and lutenolin (4). Expand
Phytoestrogens from Aspalathus linearis.
From the leaves of Aspalathus linearis, 24 known compounds and a new one, aspalalinin (25), were isolated. The structures of the compounds were determined mainly based on spectral evidence. TheExpand
Simultaneous determination of twelve tea catechins by high-performance liquid chromatography with electrochemical detection.
A high-performance liquid chromatographic method with electrochemical detection was developed for the determination of twelve tea catechins, sensitive to and appropriate for the simultaneous determination of various biologically active catechin in green tea. Expand
Limonoids and Quinolone Alkaloids from Evodia rutaecarpa BENTHAM
Four new limonoids and five new quinolone alkaloids were isolated from the fruit of Evodia rutaecarpa BENTHAM (Rutaceae), together with seven known limonoids and four known quinolone alkaloids, andExpand
Chemical Studies on the Constituents of Polygonum nodosum
A new cyclobutane derivative, which may be formed from dehydrokawain by [2+2] cycloaddition, named compound B (8a), mp 226-227°C, C28H24O6, and a new flavanonol, named compound C (10a), mp 142-143°C,Expand
Studies on absorption, distribution, excretion and metabolism of ginseng saponins. VII. Comparison of the decomposition modes of ginsenoside-Rb1 and -Rb2 in the digestive tract of rats.
It appears that hydrolysis by beta-glucosidase, which is present in the rat large intestine, is distinct from that by crude hesperidinase. Expand
Green tea polyphenols: novel and potent inhibitors of squalene epoxidase.
  • I. Abe, T. Seki, +4 authors T. Ono
  • Chemistry, Medicine
  • Biochemical and biophysical research…
  • 24 February 2000
It was demonstrated for the first time that the cholesterol lowering effect of green tea may be attributed to their potent SE inhibition activities, and that EGCG inhibited SE in noncompetitive, and non-time-dependent manner. Expand