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Anti‐plasmodial activity of some Kenyan medicinal plant extracts singly and in combination with chloroquine
The plants which showed activity may be useful as sources for novel anti‐plasmodial compounds and combined with chloroquine against the multi‐drug resistant P. falciparum strains revealed synergistic effect. Expand
Antimalarial activity of methanolic extracts from plants used in Kenyan ethnomedicine and their interactions with chloroquine (CQ) against a CQ-tolerant rodent parasite, in mice.
Plants, which showed significant antimalarial activity including Vernonia lasiopus, Toddalia asiatica, Ficus sur, Rhamnus prinoides and RhamNus staddo warrant further evaluation in the search for novel antimalaria agents against drug-resistant malaria. Expand
In vitro antiplasmodial activity of some plants used in Kisii, Kenya against malaria and their chloroquine potentiation effects.
The plant extracts with low IC(50) values may be used as sources for novel antimalarial compounds to be used alone or in combination with CQ. Expand
Next-Generation Antimalarial Drugs: Hybrid Molecules as a New Strategy in Drug Design
This review is focused on several hybrid molecules that have been developed, with particular emphasis on those deemed to have high potential for development for clinical use. Expand
Antiplasmodial triterpenoids from Ekebergia capensis.
Ten new triterpenoid compounds isolated from the stem bark of Ekebergia capensis were found to exhibit moderate antiplasmodial activity and were screened in vitro against both chloroquine (CQ)-sensitive and -resistant Plasmodium falciparum isolates. Expand
Anti-plasmodial activity of the extracts of some Kenyan medicinal plants.
This study revealed plants, that are potential sources of anti-malarial compounds, that were identified in Kilifi and Tharaka districts of Kenya for the first time. Expand
Plasmodium berghei: lack of antimalarial activity of an analogue of folate precursor, 2,4-diamino-6-hydroxymethylpteridine in a mouse model.
The ability of DAP to inhibit proliferation of Plasmodium berghei NK65 in mice is evaluated, with folinic acid rescue and the findings do not seem to support the hypothesis of selective de novo metabolism of D AP to AMP by the malarial parasite. Expand
In Vivo antimalarial activity of aqueous extracts from Kenyan medicinal plants and their Chloroquine (CQ) potentiation effects against a blood‐induced CQ‐resistant rodent parasite in mice
Hot water extracts from eight medicinal plants representing five families, used for malaria treatment in Kenya were screened for their in vivo antimalarial activity in mice against a chloroquine (CQ)Expand
The antiplasmodial activity of spermine alkaloids isolated from Albizia gummifera.
The methanolic extract of Albizia gummifera was fractionated into various fractions and the alkaloidal fraction exhibited strong activity against NF54 and ENT30 and showed percentage chemosuppression of parasitaemia in mice ranging from 43 to 72%. Expand
Chromosomal mapping of host resistance loci to Trichinella spiralis nematode infection in rats
The results from the present study provide more insights on host–parasite interactions, which may be useful in facilitating the development of novel approaches for treatment and control of intestinal parasites in human and domestic livestock. Expand