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fazarabine

Known as: 5 azacytosine arabinoside, Kymarabine, arabinosyl-5-azacytosine 
An orally-active pyrimidine analogue of an aza-substituted cytidine in which the ribose moiety is replaced by an arabinose sugar. Similar in action… 
National Institutes of Health

Related topics

Related topics

8 relations

Broader (4)

Antineoplastic AgentsAzacitidineCytarabineNucleoside Analogs
DNA Synthesis InhibitionDNA-Directed DNA Polymeraseanalogs & derivatives

Narrower (1)

NSC 281272

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2004
2004
Antitumor drug cross-resistance in vivo in a cisplatin-resistant murine P388 leukemia
SummarySince 1978, over 50 clinically useful antitumor drugs or new candidate antitumor agents have been evaluated in vivo… 
1992
1992
Phase II trial of fazarabine (arabinofuranosyl-5-azacytidine) in patients with advanced pancreatic adenocarcinoma
We conducted a phase II evaluation of fazarabine 1.75–2.0 mg/m2hr over 72 hours every 28 days in 14 previously untreated patients… 
1990
1990
Enhancement of the toxicity and DNA incorporation of arabinosyl-5-azacytosine and 1-beta-D-arabinofuranosylcytosine by cyclopentenyl cytosine.
We evaluated the interaction of a biochemically active concentration of cyclopentenyl cytosine (CPE-C), an investigational… 
1989
1989
Phase I trial and pharmacokinetic evaluation of fazarabine in children.
A phase I trial of fazarabine (1-beta-D-arabinofuranosyl-5-azacytosine, NSC 281272) administered as a 24-h continuous infusion… 
Review
1987
Review
1987
Arabinosyl-5-azacytosine: A novel nucleoside entering clinical trials
Arabinosyl-5-azacytosine is a new compound which has been selected by the Division of Cancer Treatment, National Cancer Institute… 
1986
1986
Mechanism of action of 1-beta-D-arabinofuranosyl-5-azacytosine and its effects in L1210 mouse leukemia cells.
Ara-5AC depresses the growth of L1210 cells in vivo in a manner that is schedule-independent and at the dose levels which are… 
1986
1986
Arabinofuranosyl-5-azacytosine: antitumor and cytotoxic properties.
Arabinofuranosyl-5-azacytosine (ara-AC), a nucleoside combining the structural elements of 5-azacytidine and… 
1985
1985
Metabolism of 1-beta-D-arabinofuranosyl-5-azacytosine and incorporation into DNA of human T-lymphoblastic cells (Molt-4).
1-beta-D-Arabinofuranosyl-5-azacytosine (ara-5-aza-Cyd) had potent cytotoxicity against human T-type lymphoblastic cells in… 
1979
1979
Synthesis and antitumor activity of 5-azacytosine arabinoside.
5-Azacytosine arabinoside (ara-AC) can be considered a combination of structural elements derived from the antitumor nucleosides… 
1977
1977
The synthesis and antitumor activity of arabinosyl-5-azacytosine.
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