Skip to search formSkip to main contentSkip to account menu

Differential phosphorylation of azidothymidine, dideoxycytidine, and dideoxyinosine in resting and activated peripheral blood mononuclear cells.

TLDR
It is concluded that AZT, ddC, and ddI exert disproportionate antiviral effects depending on the activation state of the target cells, i.e., ddI and ddC exert antiviral activity more favorably in resting cells than in activated cells, while AZT preferentially protects activated cells against HIV infection.
View on PubMed (opens in a new tab)

7-Hydroxymethotrexate as a urinary metabolite in human subjects and rhesus monkeys receiving high dose methotrexate.

TLDR
Evidence indicates that in primates, the in vivo conversion of methotrexate to 7-hydroxymethotrexate is a dose-dependent phenomenon, with the enzyme system(s) catalyzing the reaction having a low affinity for the drug.
View on PubMed (opens in a new tab)

Human liver aldehyde oxidase: differential inhibition of oxidation of charged and uncharged substrates.

  • D. Johns
  • Biology, Chemistry
    The Journal of clinical investigation
  • 1 September 1967
TLDR
This mode of oxidation appears to be unique to substrates with a positively charged quaternary nitrogen; the hydroxylation of other nonaldehydic heterocyclic substrates for the human enzyme is sensitive to conventional aldehyde oxidase inhibitors.
View on PubMed (opens in a new tab)

Cellular pharmacology of cyclopentenyl cytosine in Molt-4 lymphoblasts.

TLDR
Cytidine, uridine, and nitrobenzylthioinosine all strongly repressed the anabolic phosphorylation of CPEC when added to Molt-4 cells along with the drug, suggesting that the initial interiorization was mediated by facilitated diffusion.
View on PubMed (opens in a new tab)

Folate antagonists.

View on PubMed (opens in a new tab)

Replication of human immunodeficiency virus in monocytes. Granulocyte/macrophage colony-stimulating factor (GM-CSF) potentiates viral production yet enhances the antiviral effect mediated by…

TLDR
It is suggested that GM-CSF increases HIV-1 replication in M/M, while at the same time enhancing the anti-HIV activity of AZT and related congeners in these cells.
View PDF (opens in a new tab)

Long-term toxicity/activity profile of 2',3'-dideoxyinosine in AIDS or AIDS-related complex

View on Elsevier (opens in a new tab)

The disposition and metabolism of 2',3'-dideoxycytidine, an in vitro inhibitor of human T-lymphotrophic virus type III infectivity, in mice and monkeys.

The pharmacokinetics and metabolism of the anti-human T-lymphotrophic virus type III/lymphadenopathy-associated virus agent 2',3-dideoxycytidine have been examined in BDF1 mice and rhesus monkeys,…
View on PubMed (opens in a new tab)

Pharmacokinetics of 2′, 3′‐dideoxyadenosine and 2′, 3′‐dideoxyinosine in patients with severe human immunodeficiency virus infection

This article describes the pharmacokinetics of 2′,3′‐dideoxyadenosine (ddA) and 2′,3′‐dideoxyinosine (ddI) as determined during phase I clinical trials in patients with acquired immunodeficiency…
View on Wiley (opens in a new tab)

Arabinofuranosyl-5-azacytosine: antitumor and cytotoxic properties.

TLDR
Its broad spectrum antitumor activity, its selective toxicity to tumor cells, and its ability to produce cytodifferentiation render ara-AC of interest as a potential antineoplastic agent in humans.
View on PubMed (opens in a new tab)
...
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)