fasudil

Known as: 1-(5-Isoquinolinesulfonyl)homopiperazine, 1H-1,4-Diazepine, hexahydro-1-(5-isoquinolinylsulfonyl)-, Hexahydro-1-(5-isoquinolinylsulfonyl)-1H-1,4-diazepine 
 
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
We observed the therapeutic effect of Fasudil and explored its mechanisms in experimental autoimmune encephalomyelitis (EAE), an… (More)
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Highly Cited
2010
Highly Cited
2010
A bottleneck in drug discovery is the identification of the molecular targets of a compound (mode of action, MoA) and of its off… (More)
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Highly Cited
2009
Highly Cited
2009
OBJECTIVE Leukocyte adhesion in retinal microvasuculature substantially contributes to diabetic retinopathy. Involvement of the… (More)
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Highly Cited
2009
Highly Cited
2009
We have previously demonstrated that long-term inhibition of Rho-kinase ameliorates pulmonary arterial hypertension (PAH) in… (More)
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Highly Cited
2006
Highly Cited
2006
The ability of cancer cells to undergo invasion and migration is a prerequisite for tumor metastasis. Rho, a Ras-related small… (More)
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Highly Cited
2005
Highly Cited
2005
P ulmonary hypertension (PH) is characterised by progressive elevation of pulmonary artery pressure and pulmonary vascular… (More)
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Highly Cited
2005
Highly Cited
2005
BACKGROUND A multicenter, double-blind, placebo-controlled study was conducted to assess the efficacy and safety of fasudil, a… (More)
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Highly Cited
2003
Highly Cited
2003
OBJECTIVES We sought to determine whether a potent Rho-kinase inhibitor fasudil prevents the occurrence of myocardial ischemia in… (More)
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Highly Cited
2002
Highly Cited
2002
BACKGROUND Increased activity of Rho-kinase causes hypercontraction of vascular smooth muscle and has been implicated as playing… (More)
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Highly Cited
2002
Highly Cited
2002
Rho-kinase plays an important role in calcium sensitization for vascular smooth muscle (VSMC) contraction and may be involved in… (More)
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