John H. Zhang

Publications866
h-index85
Citations29,056
Highly Influential Citations1,117
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The importance of early brain injury after subarachnoid hemorrhage
View on Elsevier
Metamorphosis of Subarachnoid Hemorrhage Research: from Delayed Vasospasm to Early Brain Injury
TLDR
The pathological mechanisms of early brain injury after SAH are reviewed and the status of current therapies are summarized, finding that many of these mechanisms evolve with time and participate in the pathogenesis of delayed ischemic injury and poor outcome.
View on Springer
Cerebral vasospasm after subarachnoid hemorrhage: the emerging revolution
TLDR
Alternative causes of neurological deterioration and poor outcome after subarachnoid hemorrhage are proposed, including delayed effects of global cerebral ischemia, thromboembolism, microcirculatory dysfunction and cortical spreading depression.
View on Nature
NLRP3 inflammasome contributes to inflammation after intracerebral hemorrhage
TLDR
This work investigated whether NLRP3 knockdown decreases neutrophil infiltration, reduces brain edema, and improves neurological function in an intracerebral hemorrhage mouse model, and determined whether mitochondrial reactive oxygen species (ROS) governed by mitochondrial permeability transition pores (mPTPs) would triggerNLRP3 inflammasome activation following ICH.
View on Wiley
Early Brain Injury, an Evolving Frontier in Subarachnoid Hemorrhage Research
TLDR
It could be argued that the treatment of EBI may successfully attenuate some of the devastating secondary injuries and improve the outcome of patients with SAH and the reversal of vasospasm does not appear to improve patient outcome.
View on Springer
Signaling Pathways for Early Brain Injury after Subarachnoid Hemorrhage
TLDR
It is concluded that VEGF contributes to early brain injury after SAH by enhancing the activation of the MAPK pathways, and that the inhibition of these pathways might offer new treatment strategies for SAH.
View on SAGE
Mechanisms of Early Brain Injury after Subarachnoid Hemorrhage
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A new grading system evaluating bleeding scale in filament perforation subarachnoid hemorrhage rat model
View on Elsevier
Mechanisms of Early Brain Injury after Subarachnoid Hemorrhage
TLDR
Experimental data suggest that the apoptotic cascades occur very early after the initial insult and may be related directly to physiologic sequela commonly associated with SAH.
View on SAGE
Controversies and evolving new mechanisms in subarachnoid hemorrhage
View on Elsevier
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