Skip to search formSkip to main contentSkip to account menu

etoprine

Known as: DDEP, 2,4-Diamino-5-(3,4-dichlorophenyl)-6-ethylpyrimidine, 2,4-diamino-5- (3',4'-dichlorophenyl)-6-ethylpyrimidine 
A lipophilic, diaminopyrimidine folate antagonist with potential antineoplastic activity. Etoprine inhibits dihydrofolate reductase, resulting in… 
National Institutes of Health

Related topics

Related topics

3 relations
NCIt Antineoplastic Agent Terminologyanalogs & derivatives

Broader (1)

Pyrimethamine

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2018
Highly Cited
2018
Long-term trends in total inorganic nitrogen and sulfur deposition in the U.S. from 1990 to 2010.
Excess deposition (including both wet and dry deposition) of nitrogen and sulfur are detrimental to ecosystems. Recent studies… 
Highly Cited
2010
Highly Cited
2010
The discordance of diversification: evolution in the tropical‐montane frogs of the Eastern Arc Mountains of Tanzania
Species with similar geographical distribution patterns are often assumed to have a shared biogeographical history, an assumption… 
Highly Cited
1999
Highly Cited
1999
Cytochrome P450 3A degradation in isolated rat hepatocytes: 26S proteasome inhibitors as probes.
Mechanism-based inactivation of liver microsomal cytochromes P450 3A (CYP 3A, P450s 3A) in vivo and/or in vitro, via heme… 
Highly Cited
1992
Highly Cited
1992
Degradation of rat liver cytochromes P450 3A after their inactivation by 3,5-dicarbethoxy-2,6-dimethyl-4-ethyl-1,4-dihydropyridine: characterization of the proteolytic system.
1992
1992
Differential apoprotein loss of rat liver cytochromes P450 after their inactivation by 3,5-dicarbethoxy-2,6-dimethyl-4-ethyl-1,4-dihydropyridine: a case for distinct proteolytic mechanisms?
1988
1988
4-alkyl radical extrusion in the cytochrome P-450-catalyzed oxidation of 4-alkyl-1,4-dihydropyridines.
Rat liver microsomal cytochrome P-450 oxidizes the 4-methyl, 4-ethyl (DDEP), and 4-isopropyl derivatives of 3,5-bis(carbethoxy)-2… 
Highly Cited
1987
Highly Cited
1987
Degradation of rat hepatic cytochrome P-450 heme by 3,5-dicarbethoxy-2,6-dimethyl-4-ethyl-1,4-dihydropyridine to irreversibly bound protein adducts.
Highly Cited
1982
Highly Cited
1982
The catalytic mechanism of cytochrome P-450. Spin-trapping evidence for one-electron substrate oxidation.
Highly Cited
1981
Highly Cited
1981
N-Alkylprotoporphyrin IX formation in 3,5-dicarbethoxy-1,4-dihydrocollidine-treated rats. Transfer of the alkyl group from the substrate to the porphyrin.
Highly Cited
1978
Highly Cited
1978
Lipid-soluble inhibitors of dihydrofolate reductase. I. Kinetics, tissue distribution, and extent of metabolism of pyrimethamine, metoprine, and etoprine in the rat, dog, and man.
With the aim of developing anticancer compounds which overcome some of the clinical limitations of the polar dihydrofolate… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)