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etoprine

Known as: DDEP, 2,4-Diamino-5-(3,4-dichlorophenyl)-6-ethylpyrimidine, 2,4-diamino-5- (3',4'-dichlorophenyl)-6-ethylpyrimidine 
A lipophilic, diaminopyrimidine folate antagonist with potential antineoplastic activity. Etoprine inhibits dihydrofolate reductase, resulting in… 
National Institutes of Health

Related topics

Related topics

3 relations
NCIt Antineoplastic Agent Terminologyanalogs & derivatives

Broader (1)

Pyrimethamine

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
A Scheduling Algorithm for Cloud Computing System Based on the Driver of Dynamic Essential Path
To solve the problem of task scheduling in the cloud computing system, this paper proposes a scheduling algorithm for cloud… 
Review
2009
Review
2009
The Stress-Response Network in Animals: Proposals to Develop a Predictive Mathematical Model
Increasing evidence indicates that numerous genetic pathways responding to environmental stress in animals are regulated co… 
2005
2005
Heme-Reversible Impairment of CYP2B1/2 Induction in Heme-Depleted Rat Hepatocytes in Primary Culture: Translational Control by a Hepatic α-Subunit of the Eukaryotic Initiation Factor Kinase?
The role of heme in the phenobarbital-mediated induction of CYP2B1/2 was reexamined in rat hepatocytes in monolayer culture… 
2001
2001
Modulation of cyclophosphamide-based cytochrome P 450 gene therapy using liver P450 inhibitors
The sensitivity of tumors to cyclophosphamide (CPA) and other anticancer prodrugs can be substantially enhanced by transduction… 
1995
1995
The contraceptive effects of etoprine on male mice and rats.
We had previously found that 2,4-diaminopyrimidines affected spermatogenesis, possibly through the inhibition of testicular… 
1992
1992
Differential apoprotein loss of rat liver cytochromes P450 after their inactivation by 3,5-dicarbethoxy-2,6-dimethyl-4-ethyl-1,4-dihydropyridine: a case for distinct proteolytic mechanisms?
1989
1989
Tricyclic 2,4-diaminopyrimidines with broad antifolate activity and the ability to inhibit Pneumocystis carinii growth in cultured human lung fibroblasts in the presence of leucovorin.
1989
1989
Inactivation of rat hepatic cytochrome P-450 isozymes by 3,5-dicarbethoxy- 2,6-dimethyl-4-ethyl-1,4-dihydropyridine.
We have reported [Correia et al. (1987) Arch. Biochem. Biophys. 258, 436-443] that administration of 3,5-dicarbethoxy-4-ethyl-2,6… 
1982
1982
The formation of N-alkylprotoporphyrin IX and destruction of cytochrome P-450 in the liver of rats after treatment with 3,5-diethoxycarbonyl-1,4-dihydrocollidine and its 4-ethyl analog.
1975
1975
Methotrexate resistance and uptake of DDMP by L5178Y cells. Selective protection with folinic acid.
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