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Metabolism of trimethoprim in man and measurement of a new metabolite: a new fluorescence assay.
Improved procedures for extraction of polar metabolites and for enzymic cleavage of conjugated products were applied and a new metabolite, the 3-oxide of TMP, was identified, and urinary levels of this product were also measured. Expand
Lipid-soluble inhibitors of dihydrofolate reductase. I. Kinetics, tissue distribution, and extent of metabolism of pyrimethamine, metoprine, and etoprine in the rat, dog, and man.
Physicochemical properties, kinetics, and metabolism of a series of lipid-soluble 2,4-diamino-5-phenylpyrimidine folate antagonists, and pharmacokinetic studies in the mouse, rat, dog, and man indicate that metoprine has the longest plasma half-life in all four species. Expand
Synthesis and antitumor activity of 2,4-diamino-6-(2,5-dimethoxybenzyl)-5-methylpyrido[2,3-d]pyrimidine.
BW301U is a potent lipid-soluble inhibitor of mammalian dihydrofolate reductase and has significant activity against the Walker 256 carcinosarcoma in rats. Expand
Specific TLC tissue residue determination of sulfadiazine following fluorescamine derivatization.
A spectrodensitometric method based upon the measurement of the fluorescence of a sulfadiazine-fluorescamine derivative formed directly on a TLC plate by dipping it into a fluorescamine solution was explored for use in specifically assaying sulfonamide mixtures. Expand
Datiscoside, a novel antileukemic cucurbitacin glycoside from Datisca glomerata.
The role of dietary nitrate and nitrite in the reductive deamination of sulfadiazine by the rat, guinea pig, and neonatal calf.
Observations strongly suggest that reductive deamination of sulfonamides is dependent on the ingestion of nitrite or the reduction of dietary nitrate to nitrite. Expand