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eponemycin

Known as: 1,2-epoxy-2-hydroxymethyl-4-(N-isooctanoylserylamino)-6-methylhept-6-ene-3-one, Heptanamide, N-(1-(hydroxymethyl)-2-((1-((2-(hydroxymethyl)oxiranyl)carbonyl)-3-methyl-3-butenyl)amino)-2-oxoethyl)-6-methyl- 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

AmidesSerine
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Epoxomicin and Eponemycin Biosynthesis Involves gem‐Dimethylation and an Acyl‐CoA Dehydrogenase‐Like Enzyme
The α′,β′‐epoxyketone moiety of proteasome inhibitors confers high binding specificity to the N‐terminal threonine in catalytic… 
Highly Cited
2014
Highly Cited
2014
Genetic basis for the biosynthesis of the pharmaceutically important class of epoxyketone proteasome inhibitors.
The epoxyketone proteasome inhibitors are an established class of therapeutic agents for the treatment of cancer. Their unique… 
2005
2005
Development and characterization of proteasome inhibitors.
Highly Cited
1999
Highly Cited
1999
Eponemycin exerts its antitumor effect through the inhibition of proteasome function.
Cell cycle progression requires the proteasome-mediated degradation of key regulatory proteins such as cyclins, cyclin-dependent… 
Highly Cited
1999
Highly Cited
1999
Proteasome inhibition by the natural products epoxomicin and dihydroeponemycin: insights into specificity and potency.
Highly Cited
1998
Highly Cited
1998
Eponemycin analogues: syntheses and use as probes of angiogenesis.
1997
1997
Inhibition of Angiogenesis by Rhizoxin, a Microbial Metabolite Containing Two Epoxide Groups
Previous studies by our and other groups have shown that microbial products containing more than one epoxide group, including… 
Highly Cited
1992
Highly Cited
1992
Epoxomicin, a new antitumor agent of microbial origin.
An actinomycete strain No. Q996-17 produced a novel compound, epoxomicin, which exhibited in vivo antitumor activity against B16… 
Highly Cited
1991
Highly Cited
1991
Eponemycin, a novel antibiotic, is a highly powerful angiogenesis inhibitor.
Highly Cited
1990
Highly Cited
1990
Eponemycin, a new antibiotic active against B16 melanoma. I. Production, isolation, structure and biological activity.
Streptomyces hygroscopicus No. P247-71(ATCC 53709)produced a novel antibiotic eponemycin which exhibited specific in vivo… 
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