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Biosynthesis of polybrominated aromatic organic compounds by marine bacteria
Polybrominated diphenyl ethers (PBDEs) and polybrominated bipyrroles are natural products that bioaccumulate in the marine food chain. PBDEs have attracted widespread attention due to theirExpand
Metagenomic discovery of polybrominated diphenyl ether biosynthesis by marine sponges
Naturally produced polybrominated diphenyl ethers (PBDEs) pervade the marine environment and structurally resemble toxic man-made brominated flame retardants. PBDEs bioaccumulate in marine animalsExpand
Indexing the Pseudomonas specialized metabolome enabled the discovery of poaeamide B and the bananamides
Pseudomonads are cosmopolitan microorganisms able to produce a wide array of specialized metabolites. These molecules allow Pseudomonas to scavenge nutrients, sense population density and enhance orExpand
Multiple, Novel Biologically Active Endophytic Actinomycetes Isolated from Upper Amazonian Rainforests
Microbial biodiversity provides an increasingly important source of medically and industrially useful compounds. We have isolated 14 actinomycete species from a collection of approximately 300 plantExpand
A Bacterial Quorum-Sensing Precursor Induces Mortality in the Marine Coccolithophore, Emiliania huxleyi
Interactions between phytoplankton and bacteria play a central role in mediating biogeochemical cycling and food web structure in the ocean. However, deciphering the chemical drivers of theseExpand
Biosynthesis of coral settlement cue tetrabromopyrrole in marine bacteria by a uniquely adapted brominase–thioesterase enzyme pair
Significance The majority of pharmaceuticals are inspired by natural product scaffolds that are functionalized by tailoring enzymes, such as halogenases. The degree of halogenation is an importantExpand
Bioactive Endophytes Warrant Intensified Exploration and Conservation
Background A key argument in favor of conserving biodiversity is that as yet undiscovered biodiversity will yield products of great use to humans. However, the link between undiscovered biodiversityExpand
Genetic basis for the biosynthesis of the pharmaceutically important class of epoxyketone proteasome inhibitors.
The epoxyketone proteasome inhibitors are an established class of therapeutic agents for the treatment of cancer. Their unique α',β'-epoxyketone pharmacophore allows binding to the catalyticExpand
Effects of Actinomycete Secondary Metabolites on Sediment Microbial Communities
ABSTRACT Marine sediments harbor complex microbial communities that remain poorly studied relative to other biomes such as seawater. Moreover, bacteria in these communities produce antibiotics andExpand
Sequencing rare marine actinomycete genomes reveals high density of unique natural product biosynthetic gene clusters.
Traditional natural product discovery methods have nearly exhausted the accessible diversity of microbial chemicals, making new sources and techniques paramount in the search for new molecules.Expand