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- Publications
- Influence
Molecular Evidence for a Uniform Microbial Community in Sponges from Different Oceans
- U. Hentschel, J. Hopke, +4 authors B. Moore
- Biology, Medicine
- Applied and Environmental Microbiology
- 1 September 2002
ABSTRACT Sponges (class Porifera) are evolutionarily ancient metazoans that populate the tropical oceans in great abundances but also occur in temperate regions and even in freshwater. Sponges… Expand
Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking
- Mingxun Wang, J. Carver, +124 authors N. Bandeira
- Computer Science, Medicine
- Nature Biotechnology
- 1 August 2016
TLDR
Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature.
- P. Arnison, M. Bibb, +62 authors W. A. van der Donk
- Biology, Medicine
- Natural product reports
- 2013
This review presents recommended nomenclature for the biosynthesis of ribosomally synthesized and post-translationally modified peptides (RiPPs), a rapidly growing class of natural products. The… Expand
Genome sequencing reveals complex secondary metabolome in the marine actinomycete Salinispora tropica
- Daniel W. Udwary, Lisa Zeigler, +5 authors B. Moore
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 19 June 2007
Recent fermentation studies have identified actinomycetes of the marine-dwelling genus Salinispora as prolific natural product producers. To further evaluate their biosynthetic potential, we… Expand
Mass spectral molecular networking of living microbial colonies
- Jeramie D. Watrous, P. Roach, +11 authors P. Dorrestein
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 14 May 2012
Integrating the governing chemistry with the genomics and phenotypes of microbial colonies has been a “holy grail” in microbiology. This work describes a highly sensitive, broadly applicable, and… Expand
Minimum Information about a Biosynthetic Gene cluster.
- M. Medema, R. Kottmann, +151 authors F. Glöckner
- Biology, Medicine
- Nature chemical biology
- 18 August 2015
A wide variety of enzymatic pathways that produce specialized metabolites in bacteria, fungi and plants are known to be encoded in biosynthetic gene clusters. Information about these clusters,… Expand
Biosynthesis of the allylmalonyl-CoA extender unit for the FK506 polyketide synthase proceeds through a dedicated polyketide synthase and facilitates the mutasynthesis of analogues.
- SangJoon Mo, Dong Hwan Kim, +23 authors Y. Yoon
- Chemistry, Medicine
- Journal of the American Chemical Society
- 2 February 2011
The allyl moiety of the immunosuppressive agent FK506 is structurally unique among polyketides and critical for its potent biological activity. Here, we detail the biosynthetic pathway to… Expand
Lessons from the past and charting the future of marine natural products drug discovery and chemical biology.
- W. Gerwick, B. Moore
- Biology, Medicine
- Chemistry & biology
- 27 January 2012
Marine life forms are an important source of structurally diverse and biologically active secondary metabolites, several of which have inspired the development of new classes of therapeutic agents.… Expand
Genomic basis for natural product biosynthetic diversity in the actinomycetes.
The phylum Actinobacteria hosts diverse high G + C, Gram-positive bacteria that have evolved a complex chemical language of natural product chemistry to help navigate their fascinatingly varied… Expand
Discovery of two cyanobacterial phenylalanine ammonia lyases: kinetic and structural characterization.
- M. C. Moffitt, G. Louie, M. Bowman, J. Pence, J. Noel, B. Moore
- Biology, Medicine
- Biochemistry
- 30 January 2007
Phenylalanine ammonia lyase (PAL) catalyzes the deamination of phenylalanine to cinnamate and ammonia. While PALs are common in terrestrial plants where they catalyze the first committed step in the… Expand