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Molecular Evidence for a Uniform Microbial Community in Sponges from Different Oceans
- U. Hentschel, J. Hopke, B. Moore
- Environmental ScienceApplied and Environmental Microbiology
- 1 September 2002
A picture emerges where sponges can be viewed as highly concentrated reservoirs of so far uncultured and elusive marine microorganisms.
Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking
In GNPS, crowdsourced curation of freely available community-wide reference MS libraries will underpin improved annotations and data-driven social-networking should facilitate identification of spectra and foster collaborations.
Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature.
This review presents recommended nomenclature for the biosynthesis of ribosomally synthesized and post-translationally modified peptides (RiPPs), a rapidly growing class of natural products. The…
Genome sequencing reveals complex secondary metabolome in the marine actinomycete Salinispora tropica
- Daniel W. Udwary, Lisa Zeigler, B. Moore
- BiologyProceedings of the National Academy of Sciences
- 19 June 2007
This study firmly establishes the genus Salinispora as a rich source of drug-like molecules and importantly reveals the powerful interplay between genomic analysis and traditional natural product isolation studies.
Mass spectral molecular networking of living microbial colonies
- J. Watrous, P. Roach, P. Dorrestein
- Biology, ChemistryProceedings of the National Academy of Sciences
- 14 May 2012
The platform presented here provides a significant advancement in the ability to understand the spatiotemporal dynamics of metabolite production in live microbial colonies and communities.
Genomic basis for natural product biosynthetic diversity in the actinomycetes.
Trends in the secondary metabolomes of natural product-rich actinomycetes are highlighted in this review article, which contains 199 references.
Discovery of two cyanobacterial phenylalanine ammonia lyases: kinetic and structural characterization.
- M. Moffitt, G. Louie, M. Bowman, J. Pence, J. Noel, B. Moore
- Biology, ChemistryBiochemistry
- 30 January 2007
Two cyanobacterial PALs from cyanobacteria, in particular, Anabaena variabilis ATCC 29413 and Nostoc punctiforme ATCC 29133 are identified by screening the genome sequences of these organisms for members of the aromatic amino acid ammonia lyase family.
Lessons from the past and charting the future of marine natural products drug discovery and chemical biology.
Biosynthesis of the allylmalonyl-CoA extender unit for the FK506 polyketide synthase proceeds through a dedicated polyketide synthase and facilitates the mutasynthesis of analogues.
- SangJoon Mo, Dong Hwan Kim, Y. Yoon
- Biology, ChemistryJournal of the American Chemical Society
- 2 February 2011
This unique feature of FK506 biosynthesis, in which a dedicated PKS provides an atypical extender unit for the main modular PKS, illuminates a new strategy for the combinatorial biosynthesis of designer macrolide scaffolds as well as FK505 analogues.