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Antiangiogenic and Antitumor Activities of IL-271
TLDR
The evaluation of the antitumor and antiangiogenic activities of IL-27 using poorly immunogenic murine melanoma B16F10 tumors, which were engineered to overexpress single-chainIL-27, suggests that IL- 27 possesses potent antiangIogenic activity, which plays an important role in its antitumors and antimetastatic activities. Expand
Bovine lactoferrin inhibits tumor‐induced angiogenesis
TLDR
It is suggested that bLF participates as a regulator of angiogenesis, possibly explained by blocking endothelial function and inducing IL‐18 production, which may contribute to antitumor activity. Expand
Inhibition of angiogenesis by humulone, a bitter acid from beer hop.
TLDR
Humulone is a potentAngiogenic inhibitor, and may be a novel powerful tool for the therapy of various angiogenic diseases involving solid tumor growth and metastasis. Expand
Orally administered bovine lactoferrin induces caspase-1 and interleukin-18 in the mouse intestinal mucosa: a possible explanation for inhibition of carcinogenesis and metastasis.
TLDR
The possibility that elevation of caspase-1 activity by bLF and its hydrolysate may be important for production of mature IL-18 in vivo, and thus in potentiating the killing activity of T and NK cells against tumor cells is demonstrated. Expand
Characterization of tynorphin, a potent endogenous inhibitor of dipeptidyl peptidaseIII
TLDR
Results indicated that tynorphin had a more effective structure for expression of inhibitory activity toward DPPIII, suggesting that tyNorphin is a specific inhibitor of DPP III. Expand
Inhibitory effects of spinorphin, a novel endogenous regulator, on chemotaxis, O2- generation, and exocytosis by N-formylmethionyl-leucyl-phenylalanine (FMLP)-stimulated neutrophils.
TLDR
Spinorphin may be a new endogenous inflammation-regulatory peptide that modulates the interaction of FMLP with its receptor and causes a decrease of the FMLP-induced intracellular calcium concentration [Ca2+], which acts as a second messenger leading to PMN functions. Expand
The proteasome is involved in angiogenesis.
TLDR
It is suggested that the proteasome operates in the process of angiogenesis, a phenomenon essential in important physiological and pathological settings. Expand
Novel Function of Ascorbic Acid as an Angiostatic Factor
TLDR
The findings suggest that Asc affects angiogenesis through both its antioxidant properties and the stimulation of collagen synthesis, which may be useful as a supplementary therapy in various angiogenic diseases. Expand
Design and synthesis of antiangiogenic/heparin-binding arginine dendrimer mimicking the surface of endostatin.
TLDR
Two antiangiogenic arginine-rich dendrimers are designed and synthesized, which mimic the surface structure of endostatin and have stronger in vivo antiangIogenic activity at 10 microg/CAM in the chicken embryo chorioallantoic membrane (CAM) assay. Expand
Inhibition of angiogenesis by staurosporine, a potent protein kinase inhibitor.
TLDR
The results suggest that staurosporine affected embryonic angiogenesis probably by inhibiting endothelial cell proliferation, which might support the notion that certain protein kinase(s) could be implicated in induction of angiogenic process and also suggest that it would be a useful compound for studying a mode of action ofAngiogenesis occurring in various diseases, including tumor development. Expand
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