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The bipolar mitotic kinesin Eg5 moves on both microtubules that it crosslinks
During cell division, mitotic spindles are assembled by microtubule-based motor proteins. The bipolar organization of spindles is essential for proper segregation of chromosomes, and requiresExpand
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Intraflagellar Transport Is Required in Drosophila to Differentiate Sensory Cilia but Not Sperm
BACKGROUND Intraflagellar transport (IFT) uses kinesin II to carry a multiprotein particle to the tips of eukaryotic cilia and flagella and a nonaxonemal dynein to return it to the cell body. IFTExpand
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Microtubule cross-linking triggers the directional motility of kinesin-5
Although assembly of the mitotic spindle is known to be a precisely controlled process, regulation of the key motor proteins involved remains poorly understood. In eukaryotes, homotetramericExpand
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Allosteric inhibition of kinesin-5 modulates its processive directional motility
Small-molecule inhibitors of kinesin-5 (refs. 1–3), a protein essential for eukaryotic cell division4, represent alternatives to antimitotic agents that target tubulin5,6. While tubulin is needed forExpand
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Probing cell-division phenotype space and Polo-like kinase function using small molecules
Cell-permeable small molecules that inhibit their targets on fast timescales are powerful probes of cell-division mechanisms. Such inhibitors have been identified using phenotype-based screens withExpand
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The actin-binding ERM protein Moesin binds to and stabilizes microtubules at the cell cortex
The direct interaction between the ERM protein Moesin and microtubules is required for spindle organization in metaphase and cell shape transformation after anaphase onset.
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KIF14 binds tightly to microtubules and adopts a rigor-like conformation.
The mitotic kinesin motor protein KIF14 is essential for cytokinesis during cell division and has been implicated in cerebral development and a variety of human cancers. Here we show that the mouseExpand
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Microtubule flux: drivers wanted.
  • B. Kwok, T. Kapoor
  • Biology, Medicine
  • Current opinion in cell biology
  • 1 February 2007
While the metaphase spindle maintains a constant shape and size during cell division, its major component microtubules are continuously being polymerized, depolymerized and transported towards theExpand
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Adaptive Resistance to an Inhibitor of Chromosomal Instability in Human Cancer Cells.
Karyotype diversity is a hallmark of solid tumors that contributes to intratumor heterogeneity. This diversity is generated by persistent chromosome mis-segregation associated with chromosomalExpand
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Structural studies of the eIF4E–VPg complex reveal a direct competition for capped RNA: Implications for translation
Significance RNA processing including covalent modifications (e.g., the addition of the methyl-7-guanosine [m7G] “cap” on the 5′ end of transcripts) centrally influences the proteome. For example,Expand
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