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Arabidopsis lysin-motif proteins LYM1 LYM3 CERK1 mediate bacterial peptidoglycan sensing and immunity to bacterial infection
It is shown that PGN sensing and immunity to bacterial infection in Arabidopsis thaliana requires three lysin-motif (LysM) domain proteins, and proposed that lineage-specific PGN perception systems have arisen through convergent evolution.
Production of fungal and bacterial growth modulating secondary metabolites is widespread among mycorrhiza-associated streptomycetes
Mycorrhiza associated streptomycetes appear to have an important role in inhibiting the growth of fungi and bacteria, and potentially novel metabolites were produced by strains that were less antagonistic to fungi.
Phage P1-Derived Artificial Chromosomes Facilitate Heterologous Expression of the FK506 Gene Cluster
The PAC-based gene cluster conjugation methodology described here provides a tractable means to evaluate and manipulate FK506 biosynthesis and is readily applicable to other large gene clusters encoding natural products of interest to medicine, agriculture and biotechnology.
Distinct mechanisms contribute to immunity in the lantibiotic NAI-107 producer strain Microbispora ATCC PTA-5024.
This study demonstrates that immunity in Microbispora is not only based on one determinant but on the action of the distinct immunity proteins MlbQ, MlbYZ and MlbJ, which are encoded in the mlb cluster.
Overproduction of Ristomycin A by Activation of a Silent Gene Cluster in Amycolatopsis japonicum MG417-CF17
Using bioinformatic tools, ristomycin, a type III glycopeptide, which has antibacterial activity and which is used for the diagnosis of von Willebrand disease and Bernard-Soulier syndrome, was deduced as a possible product of the gene cluster.
Atacamycins A–C, 22-membered antitumor macrolactones produced by Streptomyces sp. C38*
Three new 22-membered macrolactone antibiotics, atacamycins A–C, were produced by Streptomyces sp. C38, a strain isolated from a hyper-arid soil collected from the Atacama Desert in the north of
Diversity of ABBA Prenyltransferases in Marine Streptomyces sp. CNQ-509: Promiscuous Enzymes for the Biosynthesis of Mixed Terpenoid Compounds
The efficient conversion of dihydroxynaphthalene derivatives by CnqP3 and the co-location of AA958_24325 with genes characteristic for the biosynthesis of THN-derived natural products indicates that the enzyme is involved in the formation of debromomarinone or other naphthoquinone-derived meroterpenoids.
Streptocollin, a Type IV Lanthipeptide Produced by Streptomyces collinus Tü 365
The identification and isolation of streptocollin from Streptomyces collinus Tü 365, a new member of class IV lanthipeptides, is reported, the first report on the isolation of a class’s IV lanthipingptide in preparative amounts, and on the successful heterologous expression of aclass’IV lanstipeptide gene cluster.
Polyketide Bioderivatization Using the Promiscuous Acyltransferase KirCII.
This work exploits the promiscuity of KirCII to generate new kirromycins with allyl- and propargyl-side chains in vivo, and the latter were utilized as educts for further modification by "click" chemistry.