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enadoline

Known as: N-methyl-N-(7-(1-pyrolidinyl)-1-oxaspiro(4,5)dec-8-yl)-4-benzofuranacetamide 
National Institutes of Health

Related topics

Related topics

7 relations

Broader (4)

Anti-Arrhythmia AgentsBenzofuransNeuroprotective AgentsPyrrolidines

Narrower (3)

CI 977PD 129289PD 129290

Papers overview

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2005
2005
Characterization of a Novel Bivalent Morphinan Possessing κ Agonist and μ Agonist/Antagonist Properties
Previous research has shown that compounds with mixed κ and μ activity may have utility for the treatment of cocaine abuse and… 
2003
2003
Effects of mixed-action kappa/mu opioids on cocaine self-administration and cocaine discrimination by rhesus monkeys.
kappa-Opioid agonists may functionally antagonize some behavioral effects of cocaine, but the role of mixed kappa/mu receptor… 
2000
2000
Autoradiographic distribution of mu-, delta- and kappa 1-opioid stimulated [35S]guanylyl-5'-O-(gamma-thio)-triphosphate binding in human frontal cortex and cerebellum.
Opioid receptors are known to couple to G-proteins and to inhibit adenylyl cyclase. Receptor activation of G-proteins can be… 
1999
1999
Differential antagonism of the rate-decreasing effects of kappa-opioid receptor agonists by naltrexone and norbinaltorphimine.
1999
1999
Effects of somatostatin, octreotide and cortistatin on ischaemic neuronal damage following permanent middle cerebral artery occlusion in the rat
Abstract. This study investigated whether peptides acting at somatostatin receptors, such as somatostatin-14, octreotide or… 
1999
1999
Enadoline, a selective κ-opioid receptor agonist shows potent antihyperalgesic and antiallodynic actions in a rat model of surgical pain
1995
1995
Analysis of the antinociceptive actions of the kappa-opioid agonist enadoline (CI-977) in neonatal and adult rats: comparison to kappa-opioid receptor mRNA ontogeny.
Earlier reports indicate that kappa-opioid agonists may be especially potent in the formalin test of tonic nociception, and that… 
Highly Cited
1993
Highly Cited
1993
Pharmacological modification of glutamate neurotoxicity in vivo
1993
1993
The effect of dizocilpine and enadoline on immediate early gene expression in the gerbil global ischaemia model
Review
1992
Review
1992
Neuropeptides. Function and clinical applications.
Neuropeptides are the most abundant chemical messengers in the brain and their major role seems to be the modulation of amine and… 
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