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Focal Cerebral Ischaemia in the Rat: 1. Description of Technique and Early Neuropathological Consequences following Middle Cerebral Artery Occlusion
The ability to produce a consistent focal ischaemic lesion in the rodent brain provides a technical approach that is sufficiently reproducible to enable investigation of the pathophysiology of ischaemia using recently developed autoradiographic and neurochemical methods. Expand
Reversible neural inactivation reveals hippocampal participation in several memory processes
It is indicated that hippocampal neural activity is necessary for both encoding and retrieval of spatial memory and for either trace consolidation or long-term storage. Expand
Calcitonin gene-related peptide: functional role in cerebrovascular regulation.
The cerebrovascular trigeminal neuronal system, in which CGRP is the most potent vasoactive constituent, may participate in a reflex or local response to excessive cerebral vasoconstriction that restores normal vascular diameter. Expand
Endothelin-1-Induced Reductions in Cerebral Blood Flow: Dose Dependency, Time Course, and Neuropathological Consequences
It is demonstrated that endothelin-1 is capable of reducing blood flow to pathologically low levels and provide a new model of controlled focal ischaemia followed by reperfusion. Expand
The glutamate antagonist MK‐801 reduces focal ischemic brain damage in the rat
The potency of MK‐801 in reducing ischemic brain damage, even when administered after the induction of ischemia, highlights the potential use of NMDA receptor antagonists for the treatment of focal cerebral ischemie in humans. Expand
Cerebral Blood Flow and Metabolism
Part 1 The anatomic bases: general and comparative anatomy of the cerebral circulation the blood vessel wall - endothelial and smooth muscle cells perivascular nerve fibres in brain vesselsExpand
Potential Animal Models of Lacunar Stroke: A Systematic Review
Some animal models produce small subcortical infarcts, but few mimic the human small vessel pathology, which could help improve understanding of human lacunar disease. Expand
Rapid Disruption of Axon–Glial Integrity in Response to Mild Cerebral Hypoperfusion
It is demonstrated that hypoperfusion leads to a rapid disruption of key proteins critical to the stability of the axon–glial connection that is mediated by a diversity of molecular events. Expand
Extension of cerebral hypoperfusion and ischaemic pathology beyond MCA territory after intraluminal filament occlusion in C57Bl/6J mice
It is demonstrated that intraluminal filament occlusion in C57Bl/6J mice leads to an occlusions duration-dependent increase in severity of cerebral hypoperfusion and extension of ischaemic pathology beyond MCA territory. Expand
The Role of Mitochondria in Glioma Pathophysiology
Definition of abnormalities in mitochondrial proteomics, membrane potential regulation, energy metabolism and intrinsic apoptotic pathway signalling in gliomas may open novel therapeutic opportunities. Expand