• Publications
  • Influence
Preclinical Evaluation of Pharmacotherapies for Treatment of Cocaine and Opioid Abuse Using Drug Self-Administration Procedures
Drug abuse is a major public health problem, and the relationship between intravenous drug abuse and AIDS underscores the need for more effective treatment medications. Animal models of drugExpand
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Modification of cocaine self-administration by buspirone (buspar®): potential involvement of D3 and D4 dopamine receptors.
Converging lines of evidence indicate that elevations in synaptic dopamine levels play a pivotal role in the reinforcing effects of cocaine, which are associated with its abuse liability. ThisExpand
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Age-related Reduction in Functional MRI Response to Photic Stimulation
Many functional imaging studies have demonstrated age-related alterations in cerebral blood flow during the resting state. However, few studies have addressed possible differences in functionalExpand
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Effects of kappa opioids on cocaine self-administration by rhesus monkeys.
Kappa opioid agonists attenuate some neurochemical and behavioral effects of cocaine and are being considered as potential treatments for cocaine dependence. The present study examined the effects ofExpand
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Hyponatremia in marathon runners due to inappropriate arginine vasopressin secretion.
PURPOSE Exercise-associated hyponatremia (EAH), as defined by a blood sodium concentration [Na+] less than 135 mmol/L, may lead to hypotonic encephalopathy with fatal cerebral edema. UnderstandingExpand
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Effects of kappa opioid agonists on cocaine- and food-maintained responding by rhesus monkeys.
  • N. Mello, S. Negus
  • Medicine
  • The Journal of pharmacology and experimental…
  • 1 August 1998
There is accumulating evidence that kappa opioid agonists attenuate cocaine's behavioral effects, and we recently reported that the kappa opioid agonists ethylketocyclazocine (EKC) and U50-488Expand
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Buprenorphine suppresses heroin use by heroin addicts.
Heroin-dependent men were given buprenorphine (a partial opiate agonist-antagonist) or a placebo under duoble-blind conditions on a clinical research ward where they could acquire heroin (21 to 40.5Expand
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Role of Dopamine D2-like Receptors in Cocaine Self-Administration: Studies with D2 Receptor Mutant Mice and Novel D2 Receptor Antagonists
Dopamine receptor subtypes have been classified generally as D1-like (e.g., D1, D5) or D2-like (D2, D3, D4), and converging evidence suggests that D2-like receptors may be especially important inExpand
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Behavioral effects of the delta-selective opioid agonist SNC80 and related compounds in rhesus monkeys.
The behavioral effects of the nonpeptidic delta opioid agonist SNC80 and a series of related piperazinyl benzamides derived from the parent compound BW373U86 were evaluated in rhesus monkeys. SNC80Expand
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Buprenorphine effects on human heroin self-administration: an operant analysis.
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