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desmethylmisonidazole

Known as: 1,2-propanediol, 3-(2-nitro-1h-imidazol-1-yl)-, DMM, 3-(2-nitro-I-imidazolyl)-1,2-propanediol 
A radiosensitizer that targets hypoxic cells and act as oxygen substitute making tumor cells sensitive to radiation damage.
National Institutes of Health

Related topics

Related topics

4 relations

Broader (3)

MisonidazoleMutagensRadiation-Sensitizing Agents
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1993
Highly Cited
1993
Comparative studies on cytotoxic and genotoxic effects of two organic mercury compounds in lymphocytes and gastric mucosa cells of sprague‐dawley rats
Human lymphocytes (HL) as well as lymphocytes (RL), hepatocytes (RH), and gastric mucosa cells (GM) of Sprague‐Dawley rats were… 
Highly Cited
1986
Highly Cited
1986
Phase I trial of the hypoxic cell radiosensitizer SR-2508: the results of the five to six week drug schedule.
Highly Cited
1984
Highly Cited
1984
Initial report of the phase I trial of the hypoxic cell radiosensitizer SR-2508.
1982
1982
Clinical experience with nitroimidazoles as radiosensitizers.
Review
1982
Review
1982
Mechanisms of hypoxic cell radiosensitization and the development of new sensitizers.
1982
1982
Sensitizers, protectors and oncogenic transformation in vitro.
1982
1982
The enhanced sensitivity of mammalian cells to killing by X rays after prolonged exposure to several nitroimidazoles.
1982
1982
Activation of misonidazole by rat liver microsomes and purified NADPH-cytochrome c reductase.
1982
1982
In vitro hypoxic cytotoxicity of nitroimidazoles: uptake and cell cycle phase specificity.
1980
1980
Drug interactions with misonidazole: effects of dexamethasone and its derivatives on the pharmacokinetics and toxicity of misonidazole in mice.
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