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desmethylmisonidazole

Known as: 1,2-propanediol, 3-(2-nitro-1h-imidazol-1-yl)-, DMM, 3-(2-nitro-I-imidazolyl)-1,2-propanediol 
A radiosensitizer that targets hypoxic cells and act as oxygen substitute making tumor cells sensitive to radiation damage.
National Institutes of Health

Related topics

Related topics

4 relations

Broader (3)

MisonidazoleMutagensRadiation-Sensitizing Agents
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2017
Highly Cited
2017
Intra-articular Recombinant Human Proteoglycan 4 Mitigates Cartilage Damage After Destabilization of the Medial Meniscus in the Yucatan Minipig
Background: Lubricin, or proteoglycan 4 (PRG4), is a glycoprotein responsible for joint boundary lubrication. PRG4 has been shown… 
2009
2009
Bone mineral density and its relationship with body mass index in postmenopausal women with type 2 diabetes mellitus in mainland China
Bone mineral density (BMD) and its association with body mass index (BMI) are uncertain in postmenopausal women with type 2… 
Highly Cited
2005
Highly Cited
2005
Multiple micronutrient supplements improve micronutrient status and anemia but not growth and morbidity of Indonesian infants: a randomized, double-blind, placebo-controlled trial.
Multiple micronutrient deficiencies are highly prevalent in Indonesia, but the interventions are still focused on single… 
Highly Cited
1993
Highly Cited
1993
Comparative studies on cytotoxic and genotoxic effects of two organic mercury compounds in lymphocytes and gastric mucosa cells of sprague‐dawley rats
Human lymphocytes (HL) as well as lymphocytes (RL), hepatocytes (RH), and gastric mucosa cells (GM) of Sprague‐Dawley rats were… 
Highly Cited
1989
Highly Cited
1989
Role of leukocytes in reperfusion injury of skeletal muscle after partial ischemia.
These experiments evaluated the leukocyte as a potential source of oxygen free radical (OFR) generation during reperfusion injury… 
Highly Cited
1986
Highly Cited
1986
Phase I trial of the hypoxic cell radiosensitizer SR-2508: the results of the five to six week drug schedule.
Highly Cited
1984
Highly Cited
1984
Initial report of the phase I trial of the hypoxic cell radiosensitizer SR-2508.
Review
1982
Review
1982
Mechanisms of hypoxic cell radiosensitization and the development of new sensitizers.
1982
1982
Sensitizers, protectors and oncogenic transformation in vitro.
1980
1980
Phenytoin shortens the half-life of the hypoxic cell radiosensitizer misonidazole in man: implications for possible reduced toxicity.
Phenytoin shortens the half-life of the hypoxic cell radiosensitizer misonidazole in man: implications for possible reduced… 
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