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Association of ABCB1/MDR1 and OPRM1 Gene Polymorphisms With Morphine Pain Relief
The pharmacokinetics and pharmacodynamics of morphine are under the control of several polymorphic genes, which can account for part of the observed interindividual variation in pain relief. WeExpand
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An increased micronucleus frequency in peripheral blood lymphocytes predicts the risk of cancer in humans.
The frequency of micronuclei (MN) in peripheral blood lymphocytes (PBL) is extensively used as a biomarker of chromosomal damage and genome stability in human populations. Much theoretical evidenceExpand
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RET exon 11 (G691S) polymorphism is significantly more frequent in sporadic medullary thyroid carcinoma than in the general population.
The RET protooncogene is constitutively activated by point mutations in hereditary medullary thyroid carcinomas (MTCs). RET somatic point mutations have also been reported in 40-50% of sporadic MTCs.Expand
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Chromosomal aberrations and SCEs as biomarkers of cancer risk.
Previous studies have suggested that the frequency of chromosomal aberrations (CAs), but not of sister chromatid exchanges (SCEs), predicts cancer risk. We have further examined this relationship inExpand
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Cigarette smoke extract induces oxidative stress and apoptosis in human lung fibroblasts.
Cigarette smoke is a mixture of chemicals having direct and/or indirect toxic effects on different lung cells. We investigated the effect of cigarette smoke on human lung fibroblasts (HFL-1)Expand
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HUman MicroNucleus project: international database comparison for results with the cytokinesis‐block micronucleus assay in human lymphocytes: I. Effect of laboratory protocol, scoring criteria, and
Micronucleus (MN) expression in peripheral blood lymphocytes is well established as a standard method for monitoring chromosome damage in human populations. The first results of an analysis of pooledExpand
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Microgel electrophoresis assay (comet test) and SCE analysis in human lymphocytes from 100 normal subjects.
Microscopic examination of individual human lymphocytes embedded in agarose, subjected to electrophoresis and stained with a fluorescent DNA-binding dye, provides a novel way of measuring DNA damageExpand
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DNA repair genetic polymorphisms and risk of colorectal cancer in the Czech Republic.
Colorectal cancer represents a complex disease where susceptibility may be influenced by genetic polymorphisms in the DNA repair system. In the present study we investigated the role of nine singleExpand
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Benzene and the genotoxicity of its metabolites. I. Transplacental activity in mouse fetuses and in their dams.
Benzene and some of its metabolites (hydroquinone, phenol, catechol, 1,2,4-benzenetriol, p-benzoquinone, o,o'-biphenol, p,p'-biphenol) have been tested for their capability to induce micronuclei inExpand
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DNA repair and cell cycle control genes and the risk of young-onset lung cancer.
Exposure to tobacco smoke and to mutagenic xenobiotics can cause various types of DNA damage in lung cells, which, if not corrected by DNA repair systems, may lead to deregulation of the cell cycleExpand
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