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Misonidazole

Known as: Misonidazole [Chemical/Ingredient], 1-(alpha-methoxymethyl ethanol)-2-Nitroimidazole, alpha-(Methoxymethyl)-2-nitro-1H-imidazole-1-ethanol 
A nitroimidazole with radiosensitizing and antineoplastic properties. Exhibiting high electron affinity, misonidazole induces the formation of free… 
National Institutes of Health

Related topics

Related topics

26 relations

Narrower (12)

2-aminomisonidazole4,5-dimethylmisonidazole4-bromomisonidazoleRB 7040

Broader (4)

Antineoplastic AgentsAntiprotozoal AgentsImidazolesRadiation-Sensitizing Agents
In BloodNCIt Antineoplastic Agent Terminologyagonistsaltretamine/cisplatin/cyclophosphamide/misonidazole protocol

Papers overview

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Highly Cited
1991
Highly Cited
1991
Effects of oxygenation and pH on tumor cell response to alkylating chemotherapy.
Highly Cited
1989
Highly Cited
1989
Demonstration of tumor-selective retention of fluorinated nitroimidazole probes by 19F magnetic resonance spectroscopy in vivo.
Highly Cited
1989
Highly Cited
1989
The differential hypoxic cytotoxicity of bioreductive agents determined in vitro by the MTT assay.
Highly Cited
1988
Highly Cited
1988
Enhancement of radiation-induced tumor cell killing by the hypoxic cell toxin SR 4233.
Review
1986
Review
1986
Biochemistry of reduction of nitro heterocycles.
Highly Cited
1984
Highly Cited
1984
Initial report of the phase I trial of the hypoxic cell radiosensitizer SR-2508.
Highly Cited
1984
Highly Cited
1984
Pharmacology and toxicology of sensitizers: mechanism studies.
Highly Cited
1984
Highly Cited
1984
2-Hydroxylaminoimidazoles--unstable intermediates in the reduction of 2-nitroimidazoles.
Review
1982
Review
1982
Potentiation of chemotherapy by hypoxic cell radiation sensitizers--a review.
Highly Cited
1978
Highly Cited
1978
Studies on the toxicity and radiosensitizing ability of misonidazole under conditions of prolonged incubation.
In vitro studies with CHO cells indicate that the 2-nitroimidazole, misonidazole, is markedly more toxic under hypoxic conditions… 
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