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Misonidazole

Known as: Misonidazole [Chemical/Ingredient], 1-(alpha-methoxymethyl ethanol)-2-Nitroimidazole, alpha-(Methoxymethyl)-2-nitro-1H-imidazole-1-ethanol 
A nitroimidazole with radiosensitizing and antineoplastic properties. Exhibiting high electron affinity, misonidazole induces the formation of free… Expand
National Institutes of Health

Papers overview

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Highly Cited
2007
Highly Cited
2007
Abstract Background and purpose PET with 18 F-Misonidazole (FMISO-PET) is a non-invasive method for measuring tumor hypoxia. We… Expand
Highly Cited
2005
Highly Cited
2005
UNLABELLED In radiotherapy of head and neck cancer (HNC) and non-small cell lung cancer (NSCLC), hypoxia is known to be an… Expand
Highly Cited
1995
Highly Cited
1995
To correlate misonidazole concentrations and oxygen pressures (Po2) at identical locations within EMT6/Ro multi‐cell spheroids… Expand
Highly Cited
1991
Highly Cited
1991
From 1979 through July 1983, 859 patients were enrolled in a Phase III RTOG Protocol (7916) evaluating the role of Misonidazole… Expand
Highly Cited
1981
Highly Cited
1981
ImagesFig. 1Fig. 2Fig. 3Fig. 4 
  • figure 2
  • figure 3
Highly Cited
1981
Highly Cited
1981
The cytotoxicities of a number of antineoplastic agents to oxygenated and hypoxic EMT6 mouse mammary tumor cells in culture were… Expand
  • table 1
Highly Cited
1981
Highly Cited
1981
Abstract Using a combination of toxicological, pharmacological and radiosensitization experiments on cells in vitro and tumors in… Expand
Highly Cited
1980
Highly Cited
1980
Ten 2-nitroimidazole radiosensitizers of electron affinity equal to that of misonidazole, but differing in their octanol:water… Expand
Highly Cited
1980
Highly Cited
1980
Reduction of the nitro group occurred when [14C]misonidazole was treated with zinc dust in aqueous solution in the presence of… Expand
Highly Cited
1979
Highly Cited
1979
  • J. Brown
  • The British journal of radiology
  • 1979
  • Corpus ID: 32051817
Abstract The proportion of viable hypoxic cells in EMT6/St/lu tumours assayed 18 and 24 hours after a dose of misonidazole (1.2… Expand