Misonidazole

Known as: Misonidazole [Chemical/Ingredient], 1-(alpha-methoxymethyl ethanol)-2-Nitroimidazole, alpha-(Methoxymethyl)-2-nitro-1H-imidazole-1-ethanol 
A nitroimidazole with radiosensitizing and antineoplastic properties. Exhibiting high electron affinity, misonidazole induces the formation of free… (More)
National Institutes of Health

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Highly Cited
2005
Highly Cited
2005
UNLABELLED In radiotherapy of head and neck cancer (HNC) and non-small cell lung cancer (NSCLC), hypoxia is known to be an… (More)
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Highly Cited
1999
Highly Cited
1999
To elucidate problems with microfungal infestation in indoor environments, a multidisciplinary collaborative pilot study… (More)
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Highly Cited
1995
Highly Cited
1995
To correlate misonidazole concentrations and oxygen pressures (Po2) at identical locations within EMT6/Ro multi-cell spheroids… (More)
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Highly Cited
1991
Highly Cited
1991
From 1979 through July 1983, 859 patients were enrolled in a Phase III RTOG Protocol (7916) evaluating the role of Misonidazole… (More)
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1987
1987
Radiolabelled misonidazole, a radiosensitizing drug that binds to viable hypoxic tumor cells, may be useful in identifying… (More)
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1987
1987
Misonidazole is a known hypoxic cell sensitizer that binds covalently in hypoxic cells. Its congeners labeled with 77Br, 75Br, or… (More)
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1984
1984
Under conditions of extreme hypoxia, metabolic products of the metabolism of misonidazole bind to cellular molecules at a rate… (More)
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Highly Cited
1981
Highly Cited
1981
The cytotoxicities of a number of antineoplastic agents to oxygenated and hypoxic EMT6 mouse mammary tumor cells in culture were… (More)
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1981
1981
The response of intramuscularly growing KHT sarcomas to the chemotherapeutic agent (1-(2-cloroethyl)-3-cyclohexyl-1-nitrosourea… (More)
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1980
1980
Reduction of the nitro group occurred when [14C]misonidazole was treated with zinc dust in aqueous solution in the presence of… (More)
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