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Misonidazole

Known as: Misonidazole [Chemical/Ingredient], 1-(alpha-methoxymethyl ethanol)-2-Nitroimidazole, alpha-(Methoxymethyl)-2-nitro-1H-imidazole-1-ethanol 
A nitroimidazole with radiosensitizing and antineoplastic properties. Exhibiting high electron affinity, misonidazole induces the formation of free… Expand
National Institutes of Health

Papers overview

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Highly Cited
2008
Highly Cited
2008
Malignancy in cancer is associated with aerobic glycolysis (Warburg effect) evidenced by increased trapping of [(18)F… Expand
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Highly Cited
2007
Highly Cited
2007
Abstract Background and purpose PET with 18 F-Misonidazole (FMISO-PET) is a non-invasive method for measuring tumor hypoxia. We… Expand
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Highly Cited
2005
Highly Cited
2005
UNLABELLED In radiotherapy of head and neck cancer (HNC) and non-small cell lung cancer (NSCLC), hypoxia is known to be an… Expand
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Review
2004
Review
2004
Decreased tissue oxygen tension is a component of many diseases. Although hypoxia can be secondary to a low inspired P02 or a… Expand
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Highly Cited
1995
Highly Cited
1995
To correlate misonidazole concentrations and oxygen pressures (Po2) at identical locations within EMT6/Ro multi‐cell spheroids… Expand
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Highly Cited
1991
Highly Cited
1991
From 1979 through July 1983, 859 patients were enrolled in a Phase III RTOG Protocol (7916) evaluating the role of Misonidazole… Expand
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Highly Cited
1983
Highly Cited
1983
[14C]Misonidazole (MISO) becomes bound to macromolecules of mammalian cells upon hypoxic incubation. Intracellular enzyme… Expand
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Highly Cited
1981
Highly Cited
1981
ImagesFig. 1Fig. 2Fig. 3Fig. 4 
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Highly Cited
1981
Highly Cited
1981
The cytotoxicities of a number of antineoplastic agents to oxygenated and hypoxic EMT6 mouse mammary tumor cells in culture were… Expand
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Highly Cited
1979
Highly Cited
1979
  • J. M. Brown
  • The British journal of radiology
  • 1979
  • Corpus ID: 32051817
Abstract The proportion of viable hypoxic cells in EMT6/St/lu tumours assayed 18 and 24 hours after a dose of misonidazole (1.2… Expand
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