Radiation-Sensitizing Agents

Among other nanoparticle systems, gold nanoparticles have been explored as radiosensitizers. While most of the research in this… (More)

Ataxia telangiectasia (A-T) mutated (ATM) is critical for cell cycle checkpoints and DNA repair. Thus, specific small molecule… (More)

BACKGROUND This randomized phase III study compared the overall survival (OS) of pemetrexed plus gemcitabine (PG) versus standard… (More)

The DNA repair enzymes, DNA-dependent protein kinase (DNA-PK) and poly(ADP-ribose) polymerase-1 (PARP-1), are key determinants of… (More)

Caffeine exposure sensitizes tumor cells to ionizing radiation and other genotoxic agents. The radiosensitizing effects of… (More)

PURPOSE A multicenter randomized and balanced double-blind trial with the objective of assessing the efficacy and tolerance of… (More)

PURPOSE We have reported that the deoxycytidine analog 2',2'difluoro-2'-deoxycytidine (dFdCyd) is a potent radiosensitizer of… (More)

BACKGROUND Despite notable technical advances in therapy for malignant gliomas during the past decade, improved patient survival… (More)

The investigational antineoplastic agent, taxol, a natural product from the yew, Taxus sp. L., is currently being evaluated in a… (More)

The cytotoxicities of a number of antineoplastic agents to oxygenated and hypoxic EMT6 mouse mammary tumor cells in culture were… (More)