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Radiobiology for the radiologist
Radiobiology for the radiologist is studied in detail in order to provide real-time information about the patient's tremor and tremor-like symptoms.
Computed tomography--an increasing source of radiation exposure.
The facts are summarized about CT scans, which involve much higher doses of radiation than plain films, and the implications for public health are summarized.
Cancer risks attributable to low doses of ionizing radiation: Assessing what we really know
- D. Brenner, R. Doll, +12 authors M. Zaider
- Biology, MedicineProceedings of the National Academy of Sciences…
- 10 November 2003
The difficulties involved in quantifying the risks of low-dose radiation are reviewed, a linear extrapolation of cancer risks from intermediate to very low doses currently appears to be the most appropriate methodology, and a linearity assumption is not necessarily the most conservative approach.
Radiation-induced second cancers: the impact of 3D-CRT and IMRT.
IMRT is likely to almost double the incidence of second malignancies compared with conventional radiotherapy from about 1% to 1.75% for patients surviving 10 years, but the numbers may be larger for longer survival (or for younger patients), but the ratio should remain the same.
Fractionation and protraction for radiotherapy of prostate carcinoma.
High dose rate (HDR) brachytherapy would be a highly appropriate modality for treating prostate cancer because of the documented relationship between cellular proliferative status and sensitivity to changes in fractionation, and prostatic tumors contain exceptionally low proportions of proliferating cells.
Intensity-modulated radiation therapy, protons, and the risk of second cancers.
- E. Hall
- MedicineInternational journal of radiation oncology…
- 1 May 2006
Intensity-modulated radiation therapy (IMRT) allows dose to be concentrated in the tumor volume while sparing normal tissues, however, the downside to IMRT is the potential to increase the number of radiation-induced second cancers, so that doubling it may not be acceptable in older patients and in children.
Radiation oncology: a century of achievements
The future of radiation oncology lies in exploiting the genetics or the microenvironment of the tumour to turn cancer from an acute disease to a chronic disease that can be treated effectively with radiation.
Cancer risks from diagnostic radiology.
Concerns arise when CT examinations are used without a proven clinical rationale, when alternative modalities could be used with equal efficacy, or when CT scans are repeated unnecessarily.
Ionizing radiation induces DNA double-strand breaks in bystander primary human fibroblasts
- M. Sokolov, L. Smilenov, E. Hall, I. Panyutin, W. Bonner, O. Sedelnikova
- Biology, MedicineOncogene
- 10 November 2005
These studies show that H2AX phosphorylation is an early step in the bystander effect and that the DNA DSBs underlying γ-H2AX focus formation may be responsible for its downstream manifestations.
Conditions for the equivalence of continuous to pulsed low dose rate brachytherapy.
The linear-quadratic formalism was used to reanalyze published low dose-rate studies on cells of human origin to obtain 36 parameter sets [alpha, beta, T1/2], where T 1/2 is the half time for sublethal damage repair and these data are consistent with those for human tumors.