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The single cell gel electrophoresis assay (comet assay): a European review.
Methods of in vitro toxicology.
Dietary synbiotics reduce cancer risk factors in polypectomized and colon cancer patients.
- J. Rafter, M. Bennett, J. K. Collins
- Medicine, BiologyThe American journal of clinical nutrition
- 1 February 2007
The prebiotic concept as induced by a synbiotic preparation-oligofructose-enriched inulin + Lactobacillus rhamnosus GG (LGG) and Bifidobacterium lactis Bb12 (BB12)-is able to reduce the risk of colon cancer in humans.
Protective role of probiotics and prebiotics in colon cancer.
- I. Wollowski, G. Rechkemmer, B. Pool-Zobel
- BiologyThe American journal of clinical nutrition
- 1 February 2001
Some of the newer studies showed that short-lived metabolite mixtures isolated from milk that was fermented with strains of Lactobacillus bulgaricus and Streptococcus thermophilus are more effective in deactivating etiologic risk factors of colon carcinogenesis than are cellular components of microorganisms.
Lactobacillus- and bifidobacterium-mediated antigenotoxicity in the colon of rats.
These studies show that most, but not all, LAB tested could strongly inhibit genotoxicity in the GI tract of the rat and that viable LAB organisms are required for the protective effect in vivo.
Consumption of vegetables reduces genetic damage in humans: first results of a human intervention trial with carotenoid-rich foods.
- B. Pool-Zobel, A. Bub, H. Müller, I. Wollowski, G. Rechkemmer
- Biology, MedicineCarcinogenesis
- 1 September 1997
The hypothesis that carotenoid containing plant products exert a cancer-protective effect via a decrease in oxidative and other damage to DNA in humans is supported.
Inulin-type fructans and reduction in colon cancer risk: review of experimental and human data
- B. Pool-Zobel
- BiologyBritish Journal of Nutrition
- 1 April 2005
Evidence has been accumulated that shows that inulin-type fructans and corresponding fermentation products reduced the risks for colon cancer, including the reduction of exposure to risk factors and suppression of tumour cell survival.
Fruit juice consumption modulates antioxidative status, immune status and DNA damage.
Potential of short chain fatty acids to modulate the induction of DNA damage and changes in the intracellular calcium concentration by oxidative stress in isolated rat distal colon cells.
The results on antigenotoxicity coupled with the findings on [Ca2+]i homeostasis indicate that molecular effects on the energy system render these non-transformed, freshly isolated colon cells to be less susceptible to H2O2.
Butyrate may enhance toxicological defence in primary, adenoma and tumor human colon cells by favourably modulating expression of glutathione S-transferases genes, an approach in nutrigenomics.
The gene expression of drug metabolism genes in primary human colon tissue, premalignant LT97 adenoma and HT29 tumor cells cultured in an appropriate medium was investigated and it was concluded that low GST expression levels were favourably altered by butyrate.