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desloratadine

Known as: 8-chloro-6,11-dihydro-11-(4-Piperidinylidene)-5H-benzo(5,6)cyclohepta(1,2-b)pyridine, desloratadine [Chemical/Ingredient], 8-Chloro-11-piperidin-4-ylidene-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine 
A long-acting piperidine derivate with selective H1 antihistaminergic and non-sedating properties. Desloratadine diminishes the typical histaminergic… 
National Institutes of Health

Related topics

Related topics

16 relations

Broader (3)

Cholinergic AntagonistsHistamine H1 Antagonists, Non-SedatingLoratadine

Narrower (2)

ClarinexSCH 34117
Desloratadine:MCnc:Pt:Bld:QnDesloratadine:MCnc:Pt:Ser/Plas:QnDesloratadine:MCnc:Pt:Urine:QnDrug Allergy

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2007
2007
Determination of loratadine and its active metabolite in human plasma by high-performance liquid chromatography with mass spectrometry detection.
Highly Cited
2007
Highly Cited
2007
Response normalized liquid chromatography nanospray ionization mass spectrometry
2007
2007
Desloratadine improves quality of life and symptom severity in patients with allergic rhinitis
Background:  Desloratadine is associated with decreased signs and symptoms and improved nasal airflow in multiple clinical trials… 
Highly Cited
2006
Highly Cited
2006
Azelastine nasal spray and desloratadine tablets in pollen-induced seasonal allergic rhinitis: a pharmacodynamic study of onset of action and efficacy
ABSTRACT Objective: To assess the efficacy and onset of action of azelastine nasal spray and desloratadine tablets in patients… 
2006
2006
Effect of desloratadine on epithelial cell granulocyte‐macrophage colony‐stimulating factor secretion and eosinophil survival
Background Second‐generation antihistamines are H1 receptor antagonists and may have additional anti‐inflammatory effects. 
Review
2004
Review
2004
Current concepts and therapeutic strategies forallergic rhinitis in school-age children
Review
2004
Review
2004
Anti‐inflammatory properties of desloratadine
Background Allergic rhinitis (AR) is associated with robust infiltration of immune cells and mediators that may contribute to… 
2004
2004
Comparative effects of desloratadine, fexofenadine, and levocetirizine on nasal adenosine monophosphate challenge in patients with perennial allergic rhinitis
Background There are no data directly comparing the relative efficacy of modern H1‐antihistamines in allergic rhinitis using… 
2003
2003
Studies on performance and sleepiness with the H1-antihistamine, desloratadine.
INTRODUCTION The purpose of this study was to establish whether the H1-antihistamine desloratadine (5 mg), the active metabolite… 
Highly Cited
2001
Highly Cited
2001
Loratadine and terfenadine interaction with nefazodone: Both antihistamines are associated with QTc prolongation
Nefazodone inhibits CYP3A; therefore coadministration with CYP3A substrates such as terfenadine or loratadine may result in… 
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