Alison D F Handford

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INTRODUCTION The purpose of this study was to establish whether the H1-antihistamine desloratadine (5 mg), the active metabolite of loratadine, is free of effects on performance and sleepiness. METHOD Effects of desloratadine (5 mg) on psychomotor performance, daytime sleep latencies, subjective sleepiness, and memory were studied in nine healthy(More)
The influence of sedation on the effect of an H-1 receptor antagonist on various cognitive functions, including memory, were evaluated. Diphenhydramine (50, 75 and 100 mg) and lorazepam (0.5 and 1.5 mg) were given on single occasions to 12 healthy volunteers (six males, six females) aged 20-33 (mean 23.4) years. Subjective assessments of sedation, sleep(More)
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