Loratadine

Known as: Loratadina, 1-Piperidinecarboxylic acid, 4-(8-chloro-5,6-dihydro-11H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-ylidene)-, ethyl ester, 4-(8-Chloro-5,6-dihydro-11H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-ylidene)-1-piperidinecarboxylic Acid Ethyl Ester 
A piperidine histamine H1-receptor antagonist with anti-allergic properties and without sedative effects. Loratadine blocks the H1 histamine receptor… (More)
National Institutes of Health

Papers overview

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2006
2006
The aim of this study was to formulate a self-emulsifying system (SES) containing a lipophilic drug, loratadine, and to explore… (More)
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Highly Cited
2002
Highly Cited
2002
BACKGROUND Children with allergic rhinitis are likely to develop asthma. OBJECTIVE The purpose of this investigation was to… (More)
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Highly Cited
2002
Highly Cited
2002
BACKGROUND Histamine and cysteinyl leukotrienes seem to be important mediators of allergic rhinitis. OBJECTIVE This multicenter… (More)
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Highly Cited
2002
Highly Cited
2002
BACKGROUND Cysteinyl leukotrienes are important proinflammatory mediators believed to have a role in allergic rhinitis… (More)
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Highly Cited
2001
Highly Cited
2001
Histamine is a multifunctional hormone that regulates smooth muscle contraction in the airways, acid secretion in the gut, and… (More)
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Highly Cited
2000
Highly Cited
2000
BACKGROUND Nasal challenge studies have suggested histamine and cysteinyl leukotrienes are important proinflammatory mediators in… (More)
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1997
1997
BACKGROUND The classic, first-generation histamine1-receptor antagonists used to treat allergic disorders frequently cause… (More)
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Highly Cited
1992
Highly Cited
1992
Children suffering from seasonal allergic rhinitis and matched normals were instructed on the use of a didactic computer… (More)
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1988
1988
The excretion of loratadine, a new nonsedating antihistamine, into human breast milk was studied in six lactating nonpregnant… (More)
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1987
1987
The dose proportionality and pharmacokinetics of loratadine, a new nonsedating antihistamine, were studied in 12 normal… (More)
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