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dalfampridine

Known as: 4-Aminopyridine, FAMPRIDINE (4-AMINOPYRIDINE), 4-Pyridinamine 
One of the POTASSIUM CHANNEL BLOCKERS, with secondary effect on calcium currents, which is used mainly as a research tool and to characterize channel… 
National Institutes of Health

Related topics

Related topics

25 relations
12 HR dalfampridine 10 MG Extended Release Oral Tablet [Ampyra]FAMPRIDINE (4-AMINOPYRIDINE) PWDRIn Bloodagonists

Narrower (15)

2,4-diaminopyridine2-amino-5-bromopyridine3,4-diaminopyridine3-methoxy-4-aminopyridine

Broader (1)

Potassium Channel Blockers

Papers overview

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Highly Cited
1998
Highly Cited
1998
Enhanced Opioid Efficacy in Opioid Dependence Is Caused by an Altered Signal Transduction Pathway
Chronic morphine administration induces adaptations in neurons resulting in opioid tolerance and dependence. Functional studies… 
Highly Cited
1996
Highly Cited
1996
Role of potassium channels in endothelium‐dependent relaxation resistant to nitroarginine in the rat hepatic artery
1 In the presence of indomethacin (IM, 10μm) and Nω‐nitro‐L‐arginine (L‐NOARG, 0.3 mM), acetylcholine (ACh) induces an… 
Highly Cited
1992
Highly Cited
1992
Differential activation of GABAA and GABAB receptors by spontaneously released transmitter.
1. Whole-cell patch-clamp techniques were used to record from dentate gyrus granule cells in adult rat brain slices when N-methyl… 
Highly Cited
1989
Highly Cited
1989
Expression of a cloned rat brain potassium channel in Xenopus oocytes.
Potassium channels are ubiquitous membrane proteins with essential roles in nervous tissue, but little is known about the… 
Highly Cited
1989
Highly Cited
1989
Contributions of a transient outward current to repolarization in human atrium.
Conventional microelectrode recordings combined with enzymatic cell dispersion methods and a single microelectrode voltage-clamp… 
Highly Cited
1987
Highly Cited
1987
Two types of transient outward currents in adult human atrial cells.
It has been suggested in a previous article [Escande et al., Am. J. Physiol. 249 (Heart Circ. Physiol. 18): H843-H850, 1985] that… 
Highly Cited
1986
Highly Cited
1986
Electrical and mechanical effects of BRL34915 in guinea‐pig isolated trachealis
1 BRL34915 (0.1–10 μM) suppressed the spontaneous tone of guinea‐pig isolated trachealis in a concentration‐dependent manner… 
Highly Cited
1979
Highly Cited
1979
Calcium‐dependent potentials in the mammalian sympathetic neurone.
1. Intracellular recordings from post‐ganglionic neurones of the rat superior cervical ganglion revealed two non‐synaptic… 
Highly Cited
1977
Highly Cited
1977
Antagonism of the paralysis produced by botulinum toxin in the rat The effects of tetraethylammonium, guanidine and 4-aminopyridine
Highly Cited
1977
Highly Cited
1977
Effects of 4-aminopyridine at the frog neuromuscular junction.
Micromolar concentrations of 4-aminopyridine (4-AP) were able to increase the amplitude of the end-plate current in frog… 
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