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Potassium Channel Blockers

Known as: Blockers, Potassium Channel, Channel Blockers, Potassium, potassium channel blocker 
A class of drugs that act by inhibition of potassium efflux through cell membranes. Blockade of potassium channels prolongs the duration of ACTION… Expand
National Institutes of Health

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3,4-diaminopyridine5,8-diethoxypsoralenAek toxinAmiodarone
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Anti-Arrhythmia AgentsIn BloodKATP ChannelsVasodilator Agents
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Papers overview

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Highly Cited
2006
Highly Cited
2006
Randomized, double-blind, placebo-controlled crossover pilot study of a potassium channel blocker in patients with septic shock*
Background:Marked potassium efflux prevents calcium entry into vascular smooth muscle cells and may be responsible for the… Expand
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Highly Cited
2006
Highly Cited
2006
Pulmonary vasoconstrictor action of KCNQ potassium channel blockers
BackgroundKCNQ channels have been widely studied in the nervous system, heart and inner ear, where they have important… Expand
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Highly Cited
2004
Highly Cited
2004
Treatment of episodic ataxia type 2 with the potassium channel blocker 4-aminopyridine
Patients with episodic ataxia type 2 (EA2) can often be successfully treated with acetazolamide. The authors report three… Expand
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Highly Cited
2004
Highly Cited
2004
The anti-hyperalgesic activity of retigabine is mediated by KCNQ potassium channel activation
Retigabine (N-(2-amino-4-(4-fluorobenzylamino)-phenyl) carbamic acid ethyl ester) has a broad anticonvulsant spectrum and is… Expand
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1996
1996
Myocardial ischemia/reperfusion protection using monophosphoryl lipid A is abrogated by the ATP-sensitive potassium channel blocker, glibenclamide.
OBJECTIVES Monophosphoryl lipid A (MLA), a detoxified derivative of the lipid A portion of the endotoxin molecule, given as a… Expand
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Highly Cited
1995
Highly Cited
1995
Mechanism of block of a human cardiac potassium channel by terfenadine racemate and enantiomers
1 The cardiac toxicity of racemic terfenadine (marked QT prolongation and polymorphic ventricular arrhythmias) is probably due to… Expand
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Highly Cited
1995
Highly Cited
1995
Endothelial release of nitric oxide contributes to the vasodilator effect of adenosine in humans.
BACKGROUND The endogenous nucleoside adenosine plays an important role in the regulation of vascular tone, especially during… Expand
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Highly Cited
1989
Highly Cited
1989
Anti-ischemic effects of the potassium channel activators pinacidil and cromakalim and the reversal of these effects with the potassium channel blocker glyburide.
The direct cardioprotective efficacy of the potassium channel activators pinacidil and cromakalim was determined in isolated… Expand
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Highly Cited
1985
Highly Cited
1985
Electrophysiological and pharmacological evidence that peripheral type benzodiazepine receptors are coupled to calcium channels in the heart.
PK 11195, an antagonist of the peripheral type benzodiazepine receptor, does not affect either the duration of the action… Expand
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Highly Cited
1978
Highly Cited
1978
3,4-diaminopyridine. A potent new potassium channel blocker.
3,4-diaminopyridine has been found to act very potently in selectively blocking the potassium channels of squid axon membranes… Expand
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