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Potassium Channel Blockers

Known as: Blockers, Potassium Channel, Channel Blockers, Potassium, potassium channel blocker 
A class of drugs that act by inhibition of potassium efflux through cell membranes. Blockade of potassium channels prolongs the duration of ACTION… 
National Institutes of Health

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Narrower (32)

3,4-diaminopyridine5,8-diethoxypsoralenAek toxinAmiodarone
Anti-Arrhythmia AgentsIn BloodKATP ChannelsVasodilator Agents

Papers overview

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Highly Cited
2006
Highly Cited
2006
Pulmonary vasoconstrictor action of KCNQ potassium channel blockers
BackgroundKCNQ channels have been widely studied in the nervous system, heart and inner ear, where they have important… 
Highly Cited
2006
Highly Cited
2006
Randomized, double-blind, placebo-controlled crossover pilot study of a potassium channel blocker in patients with septic shock*
Background:Marked potassium efflux prevents calcium entry into vascular smooth muscle cells and may be responsible for the… 
Review
2005
Review
2005
A systematic review of currently available pharmacological neuroprotective agents as a sole intervention before anticipated or induced cardiac arrest.
Highly Cited
2004
Highly Cited
2004
Treatment of episodic ataxia type 2 with the potassium channel blocker 4-aminopyridine
Patients with episodic ataxia type 2 (EA2) can often be successfully treated with acetazolamide. The authors report three… 
Highly Cited
2004
Highly Cited
2004
The anti-hyperalgesic activity of retigabine is mediated by KCNQ potassium channel activation
Retigabine (N-(2-amino-4-(4-fluorobenzylamino)-phenyl) carbamic acid ethyl ester) has a broad anticonvulsant spectrum and is… 
Highly Cited
1995
Highly Cited
1995
Mechanism of block of a human cardiac potassium channel by terfenadine racemate and enantiomers
1 The cardiac toxicity of racemic terfenadine (marked QT prolongation and polymorphic ventricular arrhythmias) is probably due to… 
Highly Cited
1995
Highly Cited
1995
Endothelial release of nitric oxide contributes to the vasodilator effect of adenosine in humans.
BACKGROUND The endogenous nucleoside adenosine plays an important role in the regulation of vascular tone, especially during… 
Highly Cited
1992
Highly Cited
1992
Canine left ventricular hypertrophy predisposes to ventricular tachycardia induction by phase 2 early afterdepolarizations after administration of BAY K 8644.
Highly Cited
1989
Highly Cited
1989
Anti-ischemic effects of the potassium channel activators pinacidil and cromakalim and the reversal of these effects with the potassium channel blocker glyburide.
The direct cardioprotective efficacy of the potassium channel activators pinacidil and cromakalim was determined in isolated… 
Highly Cited
1985
Highly Cited
1985
Electrophysiological and pharmacological evidence that peripheral type benzodiazepine receptors are coupled to calcium channels in the heart.
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