Potassium Channel Blockers

Known as: Blockers, Potassium Channel, Channel Blockers, Potassium, potassium channel blocker 
A class of drugs that act by inhibition of potassium efflux through cell membranes. Blockade of potassium channels prolongs the duration of ACTION… (More)
National Institutes of Health

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Papers overview

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2007
2007
Effects of the treatment with glibenclamide, an ATP-sensitive potassium channel blocker, on intestinal ischemia and reperfusion injury.
Intestinal ischemia and reperfusion injury is dependent on the recruitment and activation of neutrophils. Glibenclamide, an ATP… (More)
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2007
2007
Sarcoplasmic ATP-sensitive potassium channel blocker HMR1098 protects the ischemic heart: implication of calcium, complex I, reactive oxygen species and mitochondrial ATP-sensitive potassium channel.
The aim of this study was to investigate the effects of HMR1098, a selective blocker of sarcolemmal ATP-sensitive potassium… (More)
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2006
2006
Pulmonary vasoconstrictor action of KCNQ potassium channel blockers
BACKGROUND KCNQ channels have been widely studied in the nervous system, heart and inner ear, where they have important… (More)
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Highly Cited
2004
Highly Cited
2004
Treatment of episodic ataxia type 2 with the potassium channel blocker 4-aminopyridine.
Patients with episodic ataxia type 2 (EA2) can often be successfully treated with acetazolamide. The authors report three… (More)
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2004
2004
The anti-hyperalgesic activity of retigabine is mediated by KCNQ potassium channel activation
Retigabine (N-(2-amino-4-(4-fluorobenzylamino)-phenyl) carbamic acid ethyl ester) has a broad anticonvulsant spectrum and is… (More)
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1996
1996
Myocardial ischemia/reperfusion protection using monophosphoryl lipid A is abrogated by the ATP-sensitive potassium channel blocker, glibenclamide.
OBJECTIVES Monophosphoryl lipid A (MLA), a detoxified derivative of the lipid A portion of the endotoxin molecule, given as a… (More)
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Highly Cited
1995
Highly Cited
1995
Endothelial release of nitric oxide contributes to the vasodilator effect of adenosine in humans.
BACKGROUND The endogenous nucleoside adenosine plays an important role in the regulation of vascular tone, especially during… (More)
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Review
1993
Review
1993
Diuretic action of potassium channel blockers
The availability of specific potassium channel blockers has made it possible to examine their effects along the nephron on fluid… (More)
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Highly Cited
1989
Highly Cited
1989
Anti-ischemic effects of the potassium channel activators pinacidil and cromakalim and the reversal of these effects with the potassium channel blocker glyburide.
The direct cardioprotective efficacy of the potassium channel activators pinacidil and cromakalim was determined in isolated… (More)
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1978
1978
3,4-diaminopyridine. A potent new potassium channel blocker.
3,4-diaminopyridine has been found to act very potently in selectively blocking the potassium channels of squid axon membranes… (More)
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