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KATP Channels

Known as: Potassium Channels, ATP-Sensitive, KATP Channels [Chemical/Ingredient], Channels, KATP 
Heteromultimers of Kir6 channels (the pore portion) and sulfonylurea receptor (the regulatory portion) which affect function of the HEART; PANCREATIC… 
National Institutes of Health

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Related topics

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In BloodNesidioblastosisPotassium Channel BlockersProcess of secretion

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uK-ATP-1 potassium channel

Papers overview

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Review
2018
Review
2018
Cryo-electron microscopy structures and progress toward a dynamic understanding of KATP channels
Adenosine triphosphate (ATP)–sensitive K+ (KATP) channels are molecular sensors of cell metabolism. These hetero-octameric… 
Highly Cited
2006
Highly Cited
2006
Consequences of cardiac myocyte-specific ablation of KATP channels in transgenic mice expressing dominant negative Kir6 subunits.
Cardiac ATP-sensitive K+ (K(ATP)) channels are formed by Kir6.2 and SUR2A subunits. We produced transgenic mice that express… 
Highly Cited
2002
Highly Cited
2002
Differential effects of sarcolemmal and mitochondrial K(ATP) channels activated by 17 beta-estradiol on reperfusion arrhythmias and infarct sizes in canine hearts.
We have demonstrated the effects of estrogen on modulation of ATP-sensitive K(+) channels; however, the subcellular location of… 
Highly Cited
2002
Highly Cited
2002
Sarcolemmal KATP Channel Triggers Opioid-Induced Delayed Cardioprotection in the Rat
Recently, the involvement of sarcolemmal KATP (sarcKATP) channels in ischemic and pharmacological preconditioning (IPC and PPC… 
Highly Cited
2000
Highly Cited
2000
Fentanyl protects the heart against ischaemic injury via opioid receptors, adenosine A1 receptors and KATP channel linked mechanisms in rats.
We have investigated if fentanyl protects against myocardial ischaemic injury and if so, if the mechanism of this protection is… 
Highly Cited
1999
Highly Cited
1999
The N-terminus of KIR6.2 limits spontaneous bursting and modulates the ATP-inhibition of KATP channels.
KATP channels are heteromultimers of a sulfonylurea receptor SUR and KIR6.2 with the inward rectifier forming the pore which is… 
Highly Cited
1999
Highly Cited
1999
Preconditioning in immature rabbit hearts: role of KATP channels.
BACKGROUND The protective effects of ischemic preconditioning have been shown to occur in adult hearts of all species studied. We… 
Highly Cited
1997
Highly Cited
1997
Control of Rectification and Gating of Cloned KATP Channels by the Kir6.2 Subunit
KATP channels are a functional complex of sulphonylurea receptor (SUR1, SUR2) and inward rectifier K+ (Kir6.1, Kir6.2) channel… 
Highly Cited
1997
Highly Cited
1997
Phentolamine block of KATP channels is mediated by Kir6.2.
The ATP-sensitive K+-channel (KATP channel) plays a key role in insulin secretion from pancreatic beta cells. It is closed both… 
Highly Cited
1997
Highly Cited
1997
Blockade of Myocardial ATP‐sensitive Potassium Channels by Ketamine
Background: The adenosine triphosphate (ATP)‐sensitive potassium (K sub ATP) channel underlies the increase in potassium… 
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