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Truncation of Kir6.2 produces ATP-sensitive K+ channels in the absence of the sulphonylurea receptor
ATP-sensitive potassium channels (K-ATP channels) couple cell metabolism to electrical activity and are important in the physiology and pathophysiology of many tissues1. In pancreatic β-cells, K-ATPExpand
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The Obesity-Associated FTO Gene Encodes a 2-Oxoglutarate-Dependent Nucleic Acid Demethylase
Variants in the FTO (fat mass and obesity associated) gene are associated with increased body mass index in humans. Here, we show by bioinformatics analysis that FTO shares sequence motifs withExpand
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Crystal Structure of the Potassium Channel KirBac1.1 in the Closed State
The KirBac1.1 channel belongs to the inward-rectifier family of potassium channels. Here we report the structure of the entire prokaryotic Kir channel assembly, in the closed state, refined to aExpand
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Electrophysiology of the pancreatic beta-cell.
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Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetes.
BACKGROUND Patients with permanent neonatal diabetes usually present within the first three months of life and require insulin treatment. In most, the cause is unknown. Because ATP-sensitiveExpand
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Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production.
Insulin action in the central nervous system regulates energy homeostasis and glucose metabolism. To define the insulin-responsive neurons that mediate these effects, we generated mice with selectiveExpand
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Adenosine 5'-triphosphate-sensitive potassium channels.
  • F. Ashcroft
  • Biology, Medicine
  • Annual review of neuroscience
  • 1988
This review has focused on the properties of the ATP-sensitive K-channel found in cardiac and skeletal muscle, and in pancreatic beta-cells. It is conceivable that this channel will be found in otherExpand
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Switching from insulin to oral sulfonylureas in patients with diabetes due to Kir6.2 mutations.
BACKGROUND Heterozygous activating mutations in KCNJ11, encoding the Kir6.2 subunit of the ATP-sensitive potassium (K(ATP)) channel, cause 30 to 58 percent of cases of diabetes diagnosed in patientsExpand
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ATP-sensitive potassium channelopathies: focus on insulin secretion.
  • F. Ashcroft
  • Biology, Medicine
  • The Journal of clinical investigation
  • 1 August 2005
ATP-sensitive potassium (K(ATP)) channels, so named because they are inhibited by intracellular (ATP), play key physiological roles in many tissues. In pancreatic beta cells, these channels regulateExpand
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Diabetes Mellitus and the β Cell: The Last Ten Years
Diabetes is a major global problem. During the past decade, the genetic basis of various monogenic forms of the disease, and their underlying molecular mechanisms, have been elucidated. Many genesExpand
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