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3,4-diaminopyridine

Known as: Pyridine, 3,4-Diamino-, AMIFAMPRIDINE, 3,4-Pyridinediamine 
An organic compound derived from pyridine with potassium channel inhibition activity. Amifampridine inhibits potassium channel efflux, increasing the… Expand
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
In myasthenia gravis, the neuromuscular junction is impaired by the antibody-mediated loss of postsynaptic acetylcholine… Expand
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Highly Cited
2009
Highly Cited
2009
The purpose of this study was to investigate the clinical and electrophysiological efficacy of 3,4-diaminopyridine (DAP) in… Expand
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Highly Cited
2009
Highly Cited
2009
3,4-Diaminopyridine and pyridostigmine are widely used to treat Lambert-Eaton myasthenic syndrome (LEMS), either alone or in… Expand
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Highly Cited
2008
Highly Cited
2008
Now in its tenth edition, Stockley's Drug Interactions is still the most indispensible and authoritative international source of… Expand
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Highly Cited
2003
Highly Cited
2003
Background: Several drugs that primarily act on γ-aminobutyrate or muscarinic receptors have been used to treat downbeat… Expand
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Highly Cited
2000
Highly Cited
2000
Objectives: The authors report the results of a prospective, placebo-controlled, randomized study to evaluate the effectiveness… Expand
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Highly Cited
1989
Highly Cited
1989
Lambert-Eaton myasthenic syndrome is characterized by muscle weakness, hyporeflexia, and autonomic dysfunction, which result from… Expand
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Highly Cited
1984
Highly Cited
1984
We used a new drug, 3,4-diaminopyridine, to treat five patients with the Lambert-Eaton syndrome, one with a carcinoma and four… Expand
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Highly Cited
1980
Highly Cited
1980
3,4-Diaminopyridine (3,4-DAP) like 4-aminopyridine (4-AP) greatly increased stimulus-evoked transmitter release, recorded as end… Expand
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Highly Cited
1978
Highly Cited
1978
3,4-diaminopyridine has been found to act very potently in selectively blocking the potassium channels of squid axon membranes… Expand
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