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3,4-diaminopyridine

Known as: Pyridine, 3,4-Diamino-, AMIFAMPRIDINE, 3,4-Pyridinediamine 
An organic compound derived from pyridine with potassium channel inhibition activity. Amifampridine inhibits potassium channel efflux, increasing the… 
National Institutes of Health

Related topics

Related topics

6 relations

Narrower (3)

FirdapseSC10amifampridine phosphate

Broader (2)

Potassium Channel Blockersdalfampridine
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2010
2010
3,4-Diaminopyridine safety in clinical practice: an observational, retrospective cohort study
Fatigue is one of the most common and disabling symptoms of multiple sclerosis (MS) and has a significant, often underestimated… 
2001
2001
Theoretical analysis of the molecular determinants responsible for the K(+) channel blocking by aminopyridines.
1991
1991
3,4-Diaminopyridine in the treatment of congenital (hereditary) myasthenia.
Congenital or hereditary myasthenia describes a heterogeneous group of disorders in which the immune system is not implicated… 
1988
1988
Presynaptic K-channel blockade counteracts the depressant effect of adenosine in olfactory cortex
1988
1988
Phorbol ester-mediated enhancement of hippocampal noradrenaline release: which ion channels are involved?
Highly Cited
1985
Highly Cited
1985
Comparison of the action of types A and F botulinum toxin at the rat neuromuscular junction.
1985
1985
The effects of various cognition-enhancing drugs on in vitro rat hippocampal synaptosomal sodium dependent high affinity choline uptake.
1985
1985
Subsynaptosomal Calcium Distribution During Hypoxia and 3,4‐Diaminopyridine Treatment
Abstract: Previous results demonstrate that hypoxia (low oxygen) diminishes calcium uptake by synaptosomes. The present studies… 
Highly Cited
1983
Highly Cited
1983
Improvement of 8-arm maze performance in aged Fischer 344 rats with 3,4-diaminopyridine.
Short-term memory of a spatial task by male Fischer 344 rats at 3, 12, and 24 months of age was examined in a radial 8-arm maze… 
1978
1978
Reversal of antibiotic‐induced muscle paralysis by 3,4‐diaminopyridine
possible that the stimulation of HI-receptors causes release of catecholamines which in turn inhibit acid secretion through the… 
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