3,4-diaminopyridine

Known as: Pyridine, 3,4-Diamino-, Amifampridine, 3,4-Pyridinediamine 
An organic compound derived from pyridine with potassium channel inhibition activity. Amifampridine inhibits potassium channel efflux, increasing the… (More)

Topic mentions per year

Topic mentions per year

1966-2018
0102019662018

Papers overview

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Highly Cited
2003
Highly Cited
2003
BACKGROUND Several drugs that primarily act on gamma-aminobutyrate or muscarinic receptors have been used to treat downbeat… (More)
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2000
2000
OBJECTIVES The authors report the results of a prospective, placebo-controlled, randomized study to evaluate the effectiveness of… (More)
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1998
1998
We studied the electrophysiological parameters of motor performance in eight patients with multiple sclerosis and troublesome… (More)
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1995
1995
OBJECTIVE To determine whether 3,4-diaminopyridine (3,4-DAP) would improve clinical or electrophysiologic function in patients… (More)
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1990
1990
Ten patients with multiple sclerosis (MS) were enrolled in a preliminary trial of the potassium channel blocker, 3,4… (More)
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Highly Cited
1989
Highly Cited
1989
Lambert-Eaton myasthenic syndrome is characterized by muscle weakness, hyporeflexia, and autonomic dysfunction, which result from… (More)
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1985
1985
Previous results demonstrate that hypoxia (low oxygen) diminishes calcium uptake by synaptosomes. The present studies examined… (More)
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1984
1984
4-aminopyridine (4-AP) and 3,4-diaminopyridine (3,4-DAP) when injected intracisternally to anesthetized rats induced… (More)
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1983
1983
The molecular basis of the cognitive changes that accompany aging is unknown. Since several lines of evidence suggest that… (More)
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1978
1978
3,4-diaminopyridine has been found to act very potently in selectively blocking the potassium channels of squid axon membranes… (More)
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