S. Waxman

Publications916
h-index128
Citations59,858
Highly Influential Citations2,369
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International Union of Pharmacology. XLVII. Nomenclature and Structure-Function Relationships of Voltage-Gated Sodium Channels
TLDR
The molecular relationships and physiological roles of these sodium channel proteins are presented and comprehensive information on their molecular, genetic, physiological, and pharmacological properties is provided.
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Relative conduction velocities of small myelinated and non-myelinated fibres in the central nervous system.
TLDR
The analysis leading to this conclusion is based on morphological data which do not apply either to central or to peripheral fibres, so that myelinated fibres considerably smaller than 1 µm might be expected to conduct more rapidly than non-myelination fibres of similar size.
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Sodium channels in normal and pathological pain.
TLDR
The contribution of voltage-gated sodium channels to pain is reviewed, with Na(v)1.7 is of special interest because it has been linked to a spectrum of inherited human pain disorders and is upregulated along pain-signaling pathways after nervous system injuries.
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A Novel Persistent Tetrodotoxin-Resistant Sodium Current In SNS-Null And Wild-Type Small Primary Sensory Neurons
TLDR
The hyperpolarized voltage-dependence of this current, the substantial overlap of its activation and steady-state inactivation curves and its persistent nature suggest that this current is active near resting potential, where it may play an important role in regulating excitability of primary sensory neurons.
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Ionic mechanisms of anoxic injury in mammalian CNS white matter: role of Na+ channels and Na(+)-Ca2+ exchanger
TLDR
The results suggest that differences in the pathophysiology of gray and white matter anoxic injury are likely to necessitate multiple strategies for optimal CNS protection, and suggest that Ca2+ loading might occur via reverse operation of the Na(+)-Ca2+ exchanger.
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Nomenclature of Voltage-Gated Sodium Channels
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Activated Microglia Contribute to the Maintenance of Chronic Pain after Spinal Cord Injury
TLDR
An important role for activated microglia in the maintenance of chronic central below-level pain after SCI is suggested and the newly emerging role of non-neuronal immune cells as a contributing factor in post-SCI pain is supported.
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Determinants of conduction velocity in myelinated nerve fibers
TLDR
The conduction speed of any given fiber reflects a number of parameters and is not determined by any single structural characteristic.
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Changes in the expression of tetrodotoxin-sensitive sodium channels within dorsal root ganglia neurons in inflammatory pain
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Molecular changes in neurons in multiple sclerosis: altered axonal expression of Nav1.2 and Nav1.6 sodium channels and Na+/Ca2+ exchanger.
TLDR
The results demonstrate the molecular identities of the sodium channels expressed along demyelinated and degenerating axons in MS and suggest that coexpression of Nav1.6 and Na+/Ca2+ exchanger is associated with axonal degeneration in MS.
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