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- Publications
- Influence
Relative conduction velocities of small myelinated and non-myelinated fibres in the central nervous system.
- S. Waxman, M. Bennett
- Medicine, Materials Science
- Nature: New biology
- 16 August 1972
IN peripheral nerve, most axons with diameters of less than 1 µm do not have myelin sheaths, while most fibres more than 1 µm in diameter are myelinated1,2. In the central nervous system, axons as… Expand
Sodium channels in normal and pathological pain.
- S. Dib-Hajj, T. Cummins, J. A. Black, S. Waxman
- Chemistry, Medicine
- Annual review of neuroscience
- 23 June 2010
Nociception is essential for survival whereas pathological pain is maladaptive and often unresponsive to pharmacotherapy. Voltage-gated sodium channels, Na(v)1.1-Na(v)1.9, are essential for… Expand
Ionic mechanisms of anoxic injury in mammalian CNS white matter: role of Na+ channels and Na(+)-Ca2+ exchanger
- P. Stys, S. Waxman, B. Ransom
- Chemistry, Medicine
- The Journal of neuroscience : the official…
- 1 February 1992
White matter of the mammalian CNS suffers irreversible injury when subjected to anoxia/ischemia. However, the mechanisms of anoxic injury in central myelinated tracts are not well understood.… Expand
A Novel Persistent Tetrodotoxin-Resistant Sodium Current In SNS-Null And Wild-Type Small Primary Sensory Neurons
- T. Cummins, S. Dib-Hajj, J. A. Black, A. Akopian, J. Wood, S. Waxman
- Chemistry, Medicine
- The Journal of Neuroscience
- 15 December 1999
TTX-resistant (TTX-R) sodium currents are preferentially expressed in small C-type dorsal root ganglion (DRG) neurons, which include nociceptive neurons. Two mRNAs that are predicted to encode TTX-R… Expand
Changes in the expression of tetrodotoxin-sensitive sodium channels within dorsal root ganglia neurons in inflammatory pain
- J. A. Black, S. Liu, M. Tanaka, T. Cummins, S. Waxman
- Medicine
- Pain
- 1 April 2004
&NA; Nociceptive neurons within dorsal root ganglia (DRG) express multiple voltage‐gated sodium channels, of which the tetrodotoxin‐resistant (TTX‐R) channel Nav1.8 has been suggested to play a major… Expand
Downregulation of Tetrodotoxin-Resistant Sodium Currents and Upregulation of a Rapidly Repriming Tetrodotoxin-Sensitive Sodium Current in Small Spinal Sensory Neurons after Nerve Injury
- T. Cummins, S. Waxman
- Chemistry, Medicine
- The Journal of Neuroscience
- 15 May 1997
Clinical and experimental studies have shown that spinal sensory neurons become hyperexcitable after axonal injury, and electrophysiological changes have suggested that this may be attributable to… Expand
Activated Microglia Contribute to the Maintenance of Chronic Pain after Spinal Cord Injury
Traumatic spinal cord injury (SCI) results not only in motor impairment but also in chronic central pain, which can be refractory to conventional treatment approaches. It has been shown recently that… Expand
Molecular changes in neurons in multiple sclerosis: altered axonal expression of Nav1.2 and Nav1.6 sodium channels and Na+/Ca2+ exchanger.
- M. Craner, J. Newcombe, J. A. Black, C. Hartle, M. Cuzner, S. Waxman
- Chemistry, Medicine
- Proceedings of the National Academy of Sciences…
- 25 May 2004
Although voltage-gated sodium channels are known to be deployed along experimentally demyelinated axons, the molecular identities of the sodium channels expressed along axons in human demyelinating… Expand
Type III sodium channel mRNA is expressed in embryonic but not adult spinal sensory neurons, and is reexpressed following axotomy.
- S. Waxman, J. Kocsis, J. A. Black
- Biology, Medicine
- Journal of neurophysiology
- 1 July 1994
1. In situ hybridization with subtype-specific probes was used to ask whether there is a change in the types of sodium channels that are expressed in dorsal root ganglion (DRG) neurons after axotomy.… Expand
Multiple sodium channels and their roles in electrogenesis within dorsal root ganglion neurons
- A. Rush, T. Cummins, S. Waxman
- Biology, Medicine
- The Journal of physiology
- 1 February 2007
Dorsal root ganglion neurons express an array of sodium channel isoforms allowing precise control of excitability. An increasing body of literature indicates that regulation of firing behaviour in… Expand