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Ionic mechanisms underlying human atrial action potential properties: insights from a mathematical model.
- M. Courtemanche, R. Ramírez, S. Nattel
- Chemistry, Medicine
- The American journal of physiology
- 1 July 1998
It is concluded that this mathematical model of the human atrial AP reproduces a variety of observed AP behaviors and provides insights into the mechanisms of clinically important AP properties. Expand
2012 HRS/EHRA/ECAS Expert Consensus Statement on Catheter and Surgical Ablation of Atrial Fibrillation: recommendations for patient selection, procedural techniques, patient management and follow-up,…
- H. Calkins, K. Kuck, +43 authors D. Wilber
- Europace : European pacing, arrhythmias, and…
- 1 April 2012
This 2012 Consensus Statement is to provide a state-of-the-art review of the field of catheter and surgical ablation of AF and to report the findings of a Task Force, convened by the Heart Rhythm Society, the European Heart Rhythm Association, and the European Cardiac Arrhythmia Society and charged with defining the indications, techniques, and outcomes of this procedure. Expand
New ideas about atrial fibrillation 50 years on
- S. Nattel
- 10 January 2002
The prevailing model of atrial fibrillation involved multiple simultaneous re-entrant waves, but in light of new discoveries this hypothesis is now undergoing re-evaluation. Expand
Atrial fibrosis: mechanisms and clinical relevance in atrial fibrillation.
The current understanding of how atrial fibrosis creates a substrate for AF is reviewed, what is known about the mechanisms underlying fibrosis and its progression is summarized, and emerging therapeutic approaches aimed at attenuating structural remodeling to prevent AF are highlighted. Expand
Atrial Remodeling and Atrial Fibrillation: Mechanisms and Implications
The types of atrial remodeling, their underlying pathophysiology, the molecular basis of their occurrence, and finally, their potential therapeutic significance are reviewed. Expand
Arrhythmogenic ion-channel remodeling in the heart: heart failure, myocardial infarction, and atrial fibrillation.
The changes in ion channel and transporter properties associated with three important clinical and experimental paradigms: congestive heart failure, myocardial infarction, and atrial fibrillation are reviewed and important opportunities for improved therapeutic approaches are highlighted. Expand
Sustained depolarization-induced outward current in human atrial myocytes. Evidence for a novel delayed rectifier K+ current similar to Kv1.5 cloned channel currents.
Isus in human atrial myocytes is due to a very rapidly activating delayed rectifier K+ current, which shows limited slow inactivation, is insensitive to tetraethylammonium, Ba2+, and dendrotoxin, and is highly sensitive to 4AP. Expand
Promotion of atrial fibrillation by heart failure in dogs: atrial remodeling of a different sort.
Experimental CHF strongly promotes the induction of sustained AF by causing interstitial fibrosis that interferes with local conduction, with important potential implications for understanding, treating, and preventing AF related to CHF. Expand
Ionic remodeling underlying action potential changes in a canine model of atrial fibrillation.
It is concluded that sustained atrial tachycardia reduces Ito and ICa, that the reduced ICa decreases APD and APD adaptation to rate, and that these cellular changes likely account for the alterations in atrial refractoriness associated with enhanced ability to maintain AF in the model. Expand
Regional and tissue specific transcript signatures of ion channel genes in the non‐diseased human heart
- N. Gaborit, Sabrina Le Bouter, +4 authors S. Demolombe
- Biology, Medicine
- The Journal of physiology
- 1 July 2007
The first report of the global portrait of regional ion‐channel subunit‐gene expression in the non‐diseased human heart is presented, with potentially important implications for understanding regional electrophysiology, arrhythmia mechanisms, and responses to ion‐ channel blocking drugs. Expand