LTP and LTD An Embarrassment of Riches
- R. Malenka, M. Bear
- 30 September 2004
AMPA receptor trafficking and synaptic plasticity.
- R. Malinow, R. Malenka
- BiologyAnnual Review of Neuroscience
The growing literature that supports a critical role for AMPA receptors trafficking in LTP and LTD is reviewed, focusing on the roles proposed for specific AMPA receptor subunits and their interacting proteins.
Long-term potentiation--a decade of progress?
- R. Malenka, R. Nicoll
- 17 September 1999
A simple model is described that unifies much of the data that previously were viewed as contradictory about the molecular mechanisms of this long-lasting increase in synaptic strength in the hippocampus.
Neural mechanisms of addiction: the role of reward-related learning and memory.
- S. Hyman, R. Malenka, E. Nestler
- Biology, PsychologyAnnual Review of Neuroscience
- 15 June 2006
Progress in identifying candidate mechanisms of addiction is reviewed, including molecular and cellular mechanisms that underlie long-term associative memories in several forebrain circuits (involving the ventral and dorsal striatum and prefrontal cortex) that receive input from midbrain dopamine neurons.
Single cocaine exposure in vivo induces long-term potentiation in dopamine neurons
- M. Ungless, J. Whistler, R. Malenka, A. Bonci
- Biology, PsychologyNature
- 31 May 2001
It is shown that a prominent form of synaptic plasticity can be elicited by a single in vivo exposure to cocaine and therefore may be involved in the early stages of the development of drug addiction.
Involvement of a calcineurin/ inhibitor-1 phosphatase cascade in hippocampal long-term depression
- R. Mulkey, S. Endo, S. Shenolikar, R. Malenka
- 9 June 1994
A signalling pathway in which calcineurin dephosphorylates and inactivates inhibitor-1 increases PP1 activity and contributes to the generation of LTD, which is suggested to be an activity-dependent decrease in synaptic efficacy.
Regulation of AMPA receptor endocytosis by a signaling mechanism shared with LTD
- E. Beattie, R. Carroll, R. Malenka
- BiologyNature Neuroscience
- 1 December 2000
It is shown that activation of NMDA receptors alone can trigger AMPA receptor endocytosis through calcium influx and activation of the calcium-dependent protein phosphatase calcineurin, and that a distinct signaling mechanism mediates the AMPA receptors endocyTosis stimulated by insulin.
Input-specific control of reward and aversion in the ventral tegmental area
- S. Lammel, B. Lim, R. Malenka
- Biology, PsychologyNature
- 23 August 2012
It is established that distinct VTA circuits generate reward and aversion, and thereby provides a new framework for understanding the circuit basis of adaptive and pathological motivated behaviours.
Evidence for silent synapses: Implications for the expression of LTP
- J. Isaac, R. Nicoll, R. Malenka
- Biology, PsychologyNeuron
- 1 August 1995
Synaptic Plasticity: Multiple Forms, Functions, and Mechanisms
- A. Citri, R. Malenka
- Biology, PsychologyNeuropsychopharmacology
Current understanding of the mechanisms of the major forms of synaptic plasticity at excitatory synapses in the mammalian brain are reviewed.